Antivascular therapy of cancer: DMXAA. (Q35080280)

6 August 2017

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title

Antivascular therapy of cancer: DMXAA. (English)

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6 August 2017

Bruce C Baguley

1

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6 August 2017

1 March 2003

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Lancet Oncology Commission

6 August 2017

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6 August 2017

4

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6 August 2017

3

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6 August 2017

141-148

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Endothelial proliferation in tumours and normal tissues: Continuous labelling studies

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Targeting tumour vasculature: the development of combretastatin A4.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

TNF-alpha induces endothelial cell F-actin depolymerization, new actin synthesis, and barrier dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Morphological change and destabilization of beta-actin mRNA by tumor necrosis factor in human microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

The relationship between elevated interstitial fluid pressure and blood flow in tumors: a bioengineering analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Blood flow failure as a major determinant in the antitumor action of flavone acetic acid.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Activity of flavone acetic acid (NSC-347512) against solid tumors of mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Flavone acetic acid--preclinical and clinical activity

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

The two different receptors for tumor necrosis factor mediate distinct cellular responses

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Acute hemorrhagic necrosis of tumors induced by interleukin-1 alpha: effects independent of tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Fever and cancer in perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Coley's toxins in perspective.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

An endotoxin-induced serum factor that causes necrosis of tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Multiple receptors for endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha)

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Decreased tumor blood flow as measured by positron emission tomography in cancer patients treated with interleukin-1 and carboplatin on a phase I trial

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Intracellular signalling involved in modulating human endothelial barrier function

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Molecular mechanisms and therapeutic strategies related to nitric oxide.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Photodynamic therapy in oncology: mechanisms and clinical use.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Vinca alkaloids: anti-vascular effects in a murine tumour

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Tumor regression by targeted gene delivery to the neovasculature

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Antitumour activity of the novel immune modulator 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice lacking the interferon-gamma receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Pulse treatment of human vascular endothelial cells with high doses of tumor necrosis factor and interferon-gamma results in simultaneous synergistic and reversible effects on proliferation and morphology

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Plasma nitrate clearance in mice: modeling of the systemic production of nitrate following the induction of nitric oxide synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Role of nitric oxide in angiogenesis and microcirculation in tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Nitric oxide: its production in host-cell-infiltrated EMT6 spheroids and its role in tumour cell killing by flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Inhibition of NF-kappa B by sodium salicylate and aspirin

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Effect of tumour necrosis factor, heat, and radiation on the viability and microfilament organization in cultured endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Tyrosine phosphorylation of vascular endothelial cadherin and the regulation of microvascular permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Potential of DMXAA combination therapy for solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Clinical measurement of blood flow in tumours using positron emission tomography: a review

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901018-0

7 January 2021

10.1016/S1470-2045(03)01018-0

Identifiers

DOI

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6 August 2017

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PubMed ID

12623359