Peptide and protein drug delivery to and into tumors: challenges and solutions (Q35080230)

6 August 2017

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title

Peptide and protein drug delivery to and into tumors: challenges and solutions (English)

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6 August 2017

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Vladimir P Torchilin

1

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PubMed ID

12623240

6 August 2017

Anatoly N Lukyanov

series ordinal

2

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6 August 2017

1 March 2003

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6 August 2017

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6 August 2017

8

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6 August 2017

6

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6 August 2017

259-266

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Somatostatin analogs and radiopeptides in cancer therapy

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Inhibition of angiogenesis: treatment options for patients with metastatic prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Clinical translation of angiogenesis inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Recent developments in depsipeptide research

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

The development and clinical use of trastuzumab (Herceptin).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

20% of sufferers could outgrow peanut allergy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

A controlled-release microchip

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Moving smaller in drug discovery and delivery.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II: Biopharmaceutical and pharmacological properties

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Pegylation: a novel process for modifying pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Introduction and overview of peptide and protein pegylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Chemistry for peptide and protein PEGylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Pegaspargase (Oncaspar)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Pegaspargase: an alternative?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Structure, biology, and therapeutic implications of pegylated interferon alpha-2b

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Pegylated interferon alfa-2b treatment for patients with solid tumors: a phase I/II study.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous Lewis lung carcinoma in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

1 reference

7 January 2021

Monoclonal antibodies in the treatment of malignancy: basic concepts and recent developments

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Anti-nuclear autoantibodies of the aged reactive against the surface of tumor but not normal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Nucleosome-releasing treatment makes surviving tumor cells better targets for nucleosome-specific anticancer antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Antibody engineering for targeted therapy of cancer: recombinant Fv-immunotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Immunotoxins: A New Approach to Cancer Therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Tumor targeting using anti-her2 immunoliposomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Mechanism-based target identification and drug discovery in cancer research

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

New drug targets for genomic cancer therapy: successes, limitations, opportunities and future challenges.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Cancer genetics: from Boveri and Mendel to microarrays

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Pharmaceutical research in molecular oncology

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Src homology-2 domains: structure, mechanisms, and drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Structural and mechanistic determinants of affinity and specificity of ligands discovered or engineered by phage display

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Bioavailability and transport of peptides and peptide drugs into the brain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Amphiphilic peptides enhance the efficiency of liposome-mediated DNA transfection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Membrane permeabilization and efficient gene transfer by a peptide containing several histidines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

A biomimetic pH-responsive polymer directs endosomal release and intracellular delivery of an endocytosed antibody complex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Application of membrane-active peptides for nonviral gene delivery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and tat: a kinetic and efficacy study

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Intercellular trafficking and protein delivery by a herpesvirus structural protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Cellular uptake of the tat protein from human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Transduction of full-length Tat fusion proteins directly into mammalian cells: analysis of T cell receptor activation-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Rho family GTPases regulate VEGF-stimulated endothelial cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

c-Rel regulation of the cell cycle in primary mouse B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

In vivo protein transduction: delivery of a biologically active protein into the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902623-0

7 January 2021

10.1016/S1359-6446(03)02623-0

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12623240