p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. (Q35079027)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

main subject

autophagy

0 references

protein ubiquitination

1 reference

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Anne Simonsen

10

1 reference

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22 January 2020

author name string

Bryan J Bartlett

1

1 reference

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22 January 2020

Pauline Isakson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Jan Lewerenz

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Heriberto Sanchez

4

1 reference

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22 January 2020

Roxanne W Kotzebue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Robert C Cumming

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Greg L Harris

7

1 reference

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22 January 2020

David R Schubert

9

1 reference

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22 January 2020

Kim D Finley

11

1 reference

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22 January 2020

publication date

1 June 2011

1 reference

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22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

volume

7

1 reference

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22 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

page(s)

572-583

1 reference

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describes a project that uses

22 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3127048/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

8 July 2018

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Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling

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Listeria monocytogenes ActA-mediated escape from autophagic recognition

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Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia

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p62 at the crossroads of autophagy, apoptosis, and cancer

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The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

8 July 2018

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Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration

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Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates

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The role of TOR in autophagy regulation from yeast to plants and mammals

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

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The cell biology of autophagy in metazoans: a developing story

8 July 2018

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ESCRT functions in autophagy and associated disease

8 July 2018

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Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

8 July 2018

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8 July 2018

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8 July 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

8 July 2018

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A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body.

8 July 2018

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8 July 2018

1 reference

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Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions.

8 July 2018

1 reference

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Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway

8 July 2018

1 reference

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Role and regulation of starvation-induced autophagy in the Drosophila fat body

8 July 2018

1 reference

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Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Hassles with taking out the garbage: aggravating aggresomes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Aggresomes, inclusion bodies and protein aggregation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Ubiquitin-protein conjugates in Alzheimer's lesions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathology.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Monitoring autophagic degradation of p62/SQSTM1.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

ESCRTs and Fab1 regulate distinct steps of autophagy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

27 September 2018

How shall I eat thee?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

The Drosophila homolog of Aut1 is essential for autophagy and development.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

A grading system of Alzheimer disease lesions in neocortical areas

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127048

Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21325881

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21325881

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/AUTO.7.6.14943

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21325881%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference