Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process? (Q35078359)

6 August 2017

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title

Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process? (English)

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6 August 2017

Yevgenya Kraytsberg

1

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6 August 2017

Ekaterina Nekhaeva

series ordinal

2

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6 August 2017

Natalya B Bodyak

series ordinal

3

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6 August 2017

Konstantin Khrapko

series ordinal

4

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6 August 2017

language of work or name

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1 January 2003

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Mechanisms of Ageing and Development

6 August 2017

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6 August 2017

124

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6 August 2017

1

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6 August 2017

49-53

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A lifetime of retinal light exposure does not appear to increase mitochondrial mutations.

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Respiratory chain failure in adult muscle fibres: relationship with ageing and possible implications for the neuronal pool.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Relaxed replication of mtDNA: A model with implications for the expression of disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mitochondria in organismal aging and degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

A proposed refinement of the mitochondrial free radical theory of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

The biologic clock: the mitochondria?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

A high frequency of mtDNA polymorphisms in HeLa cell sublines

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Cytochrome c oxidase defects of the human substantia nigra in normal aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Defects of cytochrome c oxidase in the substantia nigra of Parkinson's disease: and immunohistochemical and morphometric study.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

The 'common deletion' is not increased in parkinsonian substantia nigra as shown by competitive polymerase chain reaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Nucleotide sequence preservation of human mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Nucleotide sequence identity of mitochondrial DNA from different human tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

A mitochondrial tRNA anticodon swap associated with a muscle disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Defects of the respiratory chain in oxyphil and chief cells of the normal parathyroid and in hyperfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

mtLOH (mitochondrial loss of heteroplasmy), aging, and 'surrogate self'.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Human mitochondria: distinct organelles or dynamic network?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mutational scanning of mitochondrial DNA by two-dimensional electrophoresis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mitochondrial DNA mutations and neuromuscular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

A family exhibiting heteroplasmy in the human mitochondrial DNA control region reveals both somatic mosaicism and pronounced segregation of mitotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900169-0

7 January 2021

10.1016/S0047-6374(02)00169-0

Identifiers

DOI

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6 August 2017

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