Predicting inductive drug-drug interactions (Q35073283)

6 August 2017

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title

Predicting inductive drug-drug interactions (English)

1 reference

6 August 2017

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Christopher Liddle

1

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PubMed ID

12605548

6 August 2017

Graham R Robertson

series ordinal

2

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6 August 2017

1 March 2003

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6 August 2017

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6 August 2017

4

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6 August 2017

2

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6 August 2017

141-152

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Induction of drug-metabolizing enzymes by dioxin

6 August 2017

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

P450 genes: structure, evolution, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Counting the costs of drug-related adverse events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Clinically significant drug interactions with cyclosporin. An update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Rifampin and rifabutin drug interactions: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

St John's Wort supplements endanger the success of organ transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Oral contraceptives. Are drug interactions of clinical significance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Orphan nuclear receptors: from gene to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Growth hormone regulation of hepatic cytochrome P450 expression in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2FPHGS.4.2.141.22639

10.1517/PHGS.4.2.141.22639

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12605548