Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis (Q35061485)

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English	Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis	scientific article

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6 August 2017

Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis (English)

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6 August 2017

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10 June 2020

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10 June 2020

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10 June 2020

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10 June 2020

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Siu Wai Tsang

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10 June 2020

Haitao Xiao

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10 June 2020

Michael Wong

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10 June 2020

Hongcai Shang

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10 June 2020

Aiping Lu

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10 June 2020

Zhaoxiang Bian

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10 June 2020

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3 December 2013

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6 August 2017

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10 June 2020

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10 June 2020

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10 June 2020

e82201

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10 June 2020

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Creative Commons Attribution 3.0 Unported

3 December 2013

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Pancreatic stellate cells: a starring role in normal and diseased pancreas

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Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

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8 July 2018

Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans

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8 July 2018

Hedgehog-Gli pathway activation during kidney fibrosis

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8 July 2018

Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis

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8 July 2018

The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance

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8 July 2018

StellaTUM: current consensus and discussion on pancreatic stellate cell research

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8 July 2018

Rhein induces apoptosis in human breast cancer cells

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8 July 2018

Rhein: a potential biological therapeutic drug for intervertebral disc degeneration

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8 July 2018

Novel rhein analogues as potential anticancer agents

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8 July 2018

MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling

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8 July 2018

Chronic pancreatitis

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8 July 2018

Analysis of the human pancreatic stellate cell secreted proteome

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8 July 2018

Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro

1 reference

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8 July 2018

Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice

1 reference

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8 July 2018

Oxidative damage and TGF-β differentially induce lung epithelial cell sonic hedgehog and tenascin-C expression: implications for the regulation of lung remodelling in idiopathic interstitial lung disease

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8 July 2018

Potent anti-inflammatory effects of denbinobin mediated by dual inhibition of expression of inducible no synthase and cyclooxygenase 2.

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GLI2-mediated melanoma invasion and metastasis

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8 July 2018

Pancreatic cancer

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8 July 2018

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh.

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8 July 2018

Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation

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8 July 2018

Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo

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8 July 2018

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

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8 July 2018

Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway

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8 July 2018

Mechanisms of pancreatic fibrosis.

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8 July 2018

Generation and characterization of immortalized rat pancreatic stellate cells.

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8 July 2018

The emergent design of the neural tube: prepattern, SHH morphogen and GLI code

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8 July 2018

Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis

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8 July 2018

Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis

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8 July 2018

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis

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8 July 2018

Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture.

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8 July 2018

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27 September 2018

The hedgehog system machinery controls transforming growth factor-β-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis.

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27 September 2018

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.

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27 September 2018

Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei.

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27 September 2018

Microcalorimetric assay on the antimicrobial property of five hydroxyanthraquinone derivatives in rhubarb (Rheum palmatum L.) to Bifidobacterium adolescentis

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27 September 2018

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27 September 2018

Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK.

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27 September 2018

Curcumin blocks activation of pancreatic stellate cells

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27 September 2018

Ellagic acid blocks activation of pancreatic stellate cells

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27 September 2018

Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling

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27 September 2018

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27 September 2018

Rhein inhibits liver fibrosis induced by carbon tetrachloride in rats.

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Alcoholic pancreatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioactivity of cholecystokinin analogues: CCK-8 is not more potent than CCK-33

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preventive effects and mechanisms of rhein on renal interstitial fibrosis in obstructive nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of phase I and phase II metabolic pathways of rhein: species differences and their potential relevance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0082201

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24312641%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

2013PLoSO...882201T

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24312641%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24312641%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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