Phosphate toxicity: new insights into an old problem (Q35059905)

6 August 2017

title

Phosphate toxicity: new insights into an old problem (English)

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6 August 2017

M Shawkat Razzaque

1

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6 August 2017

language of work or name

English

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publication date

1 February 2011

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6 August 2017

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6 August 2017

volume

120

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6 August 2017

issue

3

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6 August 2017

page(s)

91-97

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The dualistic role of vitamin D in vascular calcifications

6 August 2017

cites work

1 reference

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Phosphate homeostasis and the renal-gastrointestinal axis

8 July 2018

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Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

8 July 2018

1 reference

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Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372

8 July 2018

1 reference

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Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

8 July 2018

1 reference

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A potential link between phosphate and aging--lessons from Klotho-deficient mice

8 July 2018

1 reference

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In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels

8 July 2018

1 reference

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Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

8 July 2018

1 reference

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The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis

8 July 2018

1 reference

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Intestinal npt2b plays a major role in phosphate absorption and homeostasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase

8 July 2018

1 reference

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FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?

8 July 2018

1 reference

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High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling

8 July 2018

1 reference

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In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

FGFR3 and FGFR4 do not mediate renal effects of FGF23.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Vitamin D deficiency and risk of cardiovascular disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Premature aging in klotho mutant mice: cause or consequence?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Klotho converts canonical FGF receptor into a specific receptor for FGF23

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

The kidney and bone metabolism: Nephrologists' point of view.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Bone disease in idiopathic hypercalciuria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Regulation of fibroblast growth factor-23 signaling by klotho

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Phosphate diabetes, tubular phosphate reabsorption and phosphatonins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Hypophosphatemia: an update on its etiology and treatment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Structural and biochemical properties of fibroblast growth factor 23.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporter

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Cellular signaling by fibroblast growth factor receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Structural basis for fibroblast growth factor receptor activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Klotho: a fundamental regulator of aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Disease model: human aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

New insights into the pathogenesis of inherited phosphate wasting disorders.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Cellular/molecular control of renal Na/Pi-cotransport

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Hyperphosphataemia and Hypocalcaemia Induced by Hypertonic Phosphate Enema - An Experimental Study and Review of the Literature

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Brain damage following a hypertonic phosphate enema

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Hypocalcemic coma following two pediatric phosphate enemas.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Injury by hypertonic phosphate enema

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Does FGF23 toxicity influence the outcome of chronic kidney disease?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Prolonged increase in dietary phosphate intake alters bone mineralization in adult male rats☆

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Inhibition of intestinal sodium-dependent inorganic phosphate transport by fibroblast growth factor 23.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Severe hyperphosphatemia and hypocalcemia following the rectal administration of a phosphate-containing Fleet pediatric enema

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Cola beverage consumption induces bone mineralization reduction in ovariectomized rats

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

Inorganic Phosphate Is Transported into Mitochondria in the Absence of ATP Biosynthesis: Anin Vivo31P NMR Study in the Human Skeletal Muscle

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120105

FGF-23, vitamin D and calcification: the unholy triad

25 October 2018

1 reference

12 December 2020

Toward a better understanding of Klotho

1 reference

12 December 2020

Severe hyperphosphatemia and hypocalcemic tetany after oral laxative administration in a 3-month-old infant

1 reference

12 December 2020

A fatal small dose of phosphate enema in a young child with no renal or gastrointestinal abnormality

1 reference

12 December 2020

Molecular targets of hyperphosphataemia in chronic renal failure

1 reference

12 December 2020

Fluid and Serum Electrolyte Disturbances as a Complication of Enemas in Hirschsprung's Disease

1 reference

12 December 2020

Fatal poisoning from sodium phosphate enema. Case report and experimental study

1 reference

12 December 2020

A phosphorus-31 NMR study of mitochondrial inorganic phosphate visibility: effects of calcium(2+) and manganese(2+) and the pH gradient

1 reference

12 December 2020

Fatal hyperphosphatemia after oral phosphate overdose in a premature infant

1 reference

12 December 2020

Acute effects of soft drink intake on calcium and phosphate metabolism in immature and adult rats

1 reference

12 December 2020

Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubular Na/Pi-cotransporter type II

1 reference

12 December 2020

Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in postmenopausal women

1 reference

12 December 2020

Regulation of small intestinal Na-P(i) type IIb cotransporter by dietary phosphate intake

1 reference

12 December 2020

Identifiers

DOI

10.1042/CS20100377

1 reference

6 August 2017

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6 August 2017

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