Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes (Q35059059)

6 August 2017

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title

Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes (English)

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6 August 2017

Andrei L Gartel

1

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PubMed ID

12565816

6 August 2017

Ksenya Shchors

series ordinal

2

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PubMed ID

12565816

6 August 2017

language of work or name

English

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publication date

1 February 2003

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Experimental Cell Research

6 August 2017

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6 August 2017

283

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6 August 2017

17-21

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6 August 2017

1

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Function of the c-Myc oncogenic transcription factor.

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

MYC oncogenes and human neoplastic disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

7 January 2021

c-Myc in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

The myc oncogene: MarvelouslY Complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Structure and function of helix-loop-helix proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

The Max network gone mad.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Myc-mediated transformation: the repression connection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Reduced p27Kip1 expression in hepatocellular carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Repression of p15INK4b expression by Myc through association with Miz-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

An alternative pathway for gene regulation by Myc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Variant Max protein, derived by alternative splicing, associates with c-Myc in vivo and inhibits transactivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Myc represses transcription of the growth arrest gene gas1

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Myc represses the growth arrest gene gadd45

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900020-4

10.1016/S0014-4827(02)00020-4

7 January 2021

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12565816