Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2 (Q35054374)

6 August 2017

Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2 (English)

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Herpes simplex virus type 1

6 August 2017

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M Zandian

1

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6 August 2017

K R Mott

2

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6 August 2017

S J Allen

3

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6 August 2017

O Dumitrascu

4

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6 August 2017

J Z Kuo

5

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6 August 2017

H Ghiasi

6

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6 August 2017

17 March 2011

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6 August 2017

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6 August 2017

18

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6 August 2017

7

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6 August 2017

734-742

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https://scigraph.springernature.com/pub.10.1038/gt.2011.32

6 August 2017

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The inhibitory cytokine IL-35 contributes to regulatory T-cell function

8 July 2018

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IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells

8 July 2018

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Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

8 July 2018

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Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.

8 July 2018

1 reference

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Recombinant herpes simplex virus type 1 (HSV-1) codelivering interleukin-12p35 as a molecular adjuvant enhances the protective immune response against ocular HSV-1 challenge

8 July 2018

1 reference

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DNA vaccines against human immunodeficiency virus type 1 in the past decade

8 July 2018

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Molecular phylogeny within type I cytokines and their cognate receptors

8 July 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

8 July 2018

1 reference

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Infection of BALB/c mice with a herpes simplex virus type 1 recombinant virus expressing IFN-gamma driven by the LAT promoter.

8 July 2018

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Overexpression of interleukin-2 by a recombinant herpes simplex virus type 1 attenuates pathogenicity and enhances antiviral immunity

8 July 2018

1 reference

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A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Recombinant herpes simplex virus type 1 expressing murine interleukin-4 is less virulent than wild-type virus in mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis

8 July 2018

1 reference

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Interferon-beta in multiple sclerosis: altering the balance of interleukin-12 and interleukin-10?

8 July 2018

1 reference

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8 July 2018

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Asymptomatic spinal cord lesions in clinically isolated optic nerve, brain stem, and spinal cord syndromes suggestive of demyelination

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Optic neuritis: prognosis for multiple sclerosis from MRI, CSF, and HLA findings

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Rational clinical immunotherapy for multiple sclerosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Interleukin-12 and its role in cutaneous sensitization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Local expression of tumor necrosis factor alpha and interleukin-2 correlates with protection against corneal scarring after ocular challenge of vaccinated mice with herpes simplex virus type 1.

8 July 2018

1 reference

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Optic neuritis: A population-based study in Olrnsted County, Minnesota

8 July 2018

1 reference

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Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system

8 July 2018

1 reference

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Correlation of immunological studies and disease progression in chronic progressive multiple sclerosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and gamma-IFN levels in serum and cerebrospinal fluid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

IL-4 plays a dominant role in the differential development of Tho into Th1 and Th2 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Immunological aspects of demyelinating diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118258

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

8 July 2018

1 reference

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Long-term follow-up of isolated optic neuritis: the risk of developing multiple sclerosis, its outcome, and the prognostic role of paraclinical tests.

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

Interleukin-2 gene deletion produces a robust reduction in susceptibility to experimental autoimmune encephalomyelitis in C57BL/6 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

Serial analysis of cytokine mRNA profiles in whole blood samples from patients with early multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

WSX-1: a key role in induction of chronic intestinal nematode infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

Improved protection from primary ocular HSV-1 infection and establishment of latency using multigenic DNA vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.32

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

21 January 2018

1 reference

12 December 2020

The role of T(H)1 and T(H)2 cytokines in HSV-1-induced corneal scarring

1 reference

12 December 2020

Interleukin-2 secreting cells in multiple sclerosis and controls

1 reference

12 December 2020

Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course

1 reference

12 December 2020

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells

1 reference

12 December 2020

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development

1 reference

12 December 2020

Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice

1 reference

12 December 2020

IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

1 reference

12 December 2020

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation

1 reference

12 December 2020

Interleukin-2 levels in serum and cerebrospinal fluid of multiple sclerosis patients

1 reference

12 December 2020

A long-term prospective study of optic neuritis: evaluation of risk factors

1 reference

12 December 2020

Identifiers

DOI

10.1038/GT.2011.32

1 reference

6 August 2017

1 reference

6 August 2017

1 reference