Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms (Q35049666)

6 August 2017

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title

Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms (English)

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6 August 2017

endoplasmic reticulum

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author name string

F Scott Heinemann

series ordinal

1

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PubMed ID

12538076

6 August 2017

Juris Ozols

series ordinal

2

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6 August 2017

1 February 2003

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Prostaglandins, Leukotrienes and Essential Fatty Acids

6 August 2017

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6 August 2017

68

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6 August 2017

123-133

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6 August 2017

2

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Protein degradation in the endoplasmic reticulum

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Recent advances in the biochemistry and molecular biology of fatty acyl desaturases.

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https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Structure and expression of fatty acid desaturases

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https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Dynamic lipid-bilayer heterogeneity: a mesoscopic vehicle for membrane function?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Dietary cholesterol and the activity of stearoyl CoA desaturase in rats: evidence for an indirect regulatory effect

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Fatty acid delta 5 desaturation in rat liver cell nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Cloning, expression, and fatty acid regulation of the human delta-5 desaturase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Highly increased TNF sensitivity of tumor cells expressing the yeast delta 9-desaturase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Selective activation of phospholipase D2 by unsaturated fatty acid

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Gene expression profile of aging and its retardation by caloric restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Changes in membrane fatty acids and delta-9 desaturase in senescence accelerated (SAMP8) mouse hippocampus with aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Role of tyrosyl and arginyl residues in rat liver microsomal stearylcoenzyme A desaturase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Studies on the inhibition of the desaturases by cyclopropenoid fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Degradation of hepatic stearyl CoA delta 9-desaturase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Identification of a novel SCD gene and expression of the SCD gene family in mouse skin

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Sequence analysis and characterization of FAR-17c, an androgen-dependent gene in the flank organs of hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

The control of stearoyl-CoA desaturase by dietary linoleic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Localization of a polyunsaturated fatty acid response region in stearoyl-CoA desaturase gene 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Polyunsaturated fatty acid regulation of hepatic gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Regulation of gene expression by SREBP and SCAP.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Functional analysis of secreted and transmembrane proteins critical to mouse development.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Selective mutagenesis of lysyl residues leads to a stable and active form of delta 9 stearoyl-CoA desaturase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Hereditary Absence of Sebaceous Glands in the Mouse

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https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

ER quality control: towards an understanding at the molecular level

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

ER protein quality control and proteasome-mediated protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Posttranslational quality control: folding, refolding, and degrading proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Degradation of CFTR by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

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https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Structure of the AAA ATPase p97

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

A Major Conformational Change in p97 AAA ATPase upon ATP Binding

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https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Degradation of human thyroperoxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

A two-site model for ApoB degradation in HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

Studies on degradative mechanisms mediating post-translational fragmentation of apolipoprotein B and the generation of the 70-kDa fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

A novel cytochrome b5-like domain is linked to the carboxyl terminus of the Saccharomyces cerevisiae delta-9 fatty acid desaturase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2802%2900262-4

7 January 2021

10.1016/S0952-3278(02)00262-4

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12538076