Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila (Q35046010)

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English	Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

1 reference

based on heuristic

inferred from title

Ophiorrhiza pumila

object named as

Ophiorrhiza pumila

1 reference

based on heuristic

inferred from title

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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Lijie Cui

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Xiaoling Ni

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Qian Ji

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Xiaojuan Teng

4

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1 June 2020

Yanru Yang

5

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1 June 2020

Chao Wu

6

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1 June 2020

David Zekria

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Dasheng Zhang

8

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1 June 2020

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publication date

4 February 2015

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6 August 2017

Scientific Reports

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1 June 2020

5

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1 June 2020

8227

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1 June 2020

copyright license

Creative Commons Attribution 4.0 International

4 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

https://scigraph.springernature.com/pub.10.1038/srep08227

0 references

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Cancer therapies utilizing the camptothecins: a review of the in vivo literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Molecular characterization and expression analysis of a new cDNA encoding strictosidine synthase from Ophiorrhiza japonica.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Camptothecin: therapeutic potential and biotechnology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Camptothecin, over four decades of surprising findings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Inhibition of Human Immunodeficiency Virus (HTV-1) Replication In Vitro by Noncytotoxic Doses of Camptothecin, a Topoisomerase I Inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4316170

8 July 2018

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Activity of the cytochrome P450 enzyme geraniol 10-hydroxylase and alkaloid production in plant cell cultures

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Molecular cloning and characterization of two tropinone reductases in Anisodus acutangulus and enhancement of tropane alkaloid production in AaTRI-transformed hairy roots

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants.

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Effects of methyl jasmonate and salicylic acid on tanshinone production and biosynthetic gene expression in transgenic Salvia miltiorrhiza hairy roots.

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

21 January 2018

Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral components of Ophiorrhiza mungos. Isolation of camptothecin and 10-methoxycamptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of enzymatically active cloned strictosidine synthase from the higher plant Rauvolfia serpentina in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing the production of tropane alkaloids in transgenic Anisodus acutangulus hairy root cultures by over-expressing tropinone reductase I and hyoscyamine-6β-hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25648209

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A camptothecin derivative from nothapodytes foetida

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

7 January 2021

based on heuristic

inferred from DOI database lookup

Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila

1 reference

https://api.crossref.org/works/10.1038%2FSREP08227

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SREP08227

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648209%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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