Upregulation of cytochromes P450 2B in rat liver by orphenadrine (Q35045435)

6 August 2017

title

Upregulation of cytochromes P450 2B in rat liver by orphenadrine (English)

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6 August 2017

Michael Murray

1

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6 August 2017

Eva Fiala-Beer

series ordinal

2

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6 August 2017

Dylan Sutton

series ordinal

3

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6 August 2017

language of work or name

English

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publication date

1 June 2003

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British Journal of Pharmacology

6 August 2017

published in

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6 August 2017

volume

139

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6 August 2017

issue

4

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6 August 2017

page(s)

787-796

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Protein measurement with the Folin phenol reagent

6 August 2017

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9 December 2018

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Regulation of gene expression of various phase I and phase II drug-metabolizing enzymes by tamoxifen in rat liver

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12 December 2020

An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures

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12 December 2020

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12 December 2020

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12 December 2020

Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms

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Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat

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12 December 2020

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

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12 December 2020

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Effects of dihydrosafrole on cytochromes P-450 and drug oxidation in hepatic microsomes from control and induced rats

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Product inhibition in orphenadrine metabolism as a result of a stable cytochrome P-450-metabolic intermediate complex formed during the disposition of mono-N-desmethylorphenadrine (tofenacine) in the rat

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Relationship between molecular structure and cytochrome P450-metabolic intermediate complex formation, studied with orphenadrine analogues

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Combination therapy with haloperidol and orphenadrine in schizophrenia. A clinical and pharmacokinetic study

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Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture

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Selective reactivation of steroid hydroxylases following dissociation of the isosafrole metabolite complex with rat hepatic cytochrome P-450

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Inducers of cytochrome P-450d: influence on microsomal catalytic activities and differential regulation by enzyme stabilization

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Hepatic microsomal metabolism of the anthelmintic benzimidazole fenbendazole: enhanced inhibition of cytochrome P450 reactions by oxidized metabolites of the drug

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Pretranslational down-regulation of male specific hepatic P450s after portal bypass

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cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures

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Metabolite complex formation of orphenadrine with cytochrome P450. Involvement of CYP2C11 and CYP3A isozymes

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Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ

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Identifiers

DOI

10.1038/SJ.BJP.0705305

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6 August 2017

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6 August 2017

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