Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. (Q35040174)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

1 reference

title

Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference

Michael S Saporito

1

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16 December 2019

Robert L Hudkins

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Anna C Maroney

series ordinal

3

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16 December 2019

publication date

1 January 2002

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Progress in medicinal chemistry

16 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

40

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

page(s)

23-62

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Apoptosis in the pathogenesis and treatment of disease

16 December 2019

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Parkinson's disease: pathophysiology

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

The etiology of Parkinson's disease with emphasis on the MPTP story

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

The rationale for the use of dopamine agonists in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Dopamine receptors--physiological understanding to therapeutic intervention potential

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Chronic exposure to MPTP as a primate model of progressive parkinsonism: a pilot study with a free radical scavenger

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Mitochondria in the etiology and pathogenesis of parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Origin and functional consequences of the complex I defect in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Characterization and time course of MPP+ -induced apoptosis in human SH-SY5Y neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

K-252 compounds: modulators of neurotrophin signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Animal models of Alzheimer's disease: experimental cholinergic denervation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Human brain cholinergic pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Basal forebrain neurons and memory: A biochemical, histological, and behavioral study of differential vulnerability to ibotenate and quisqualate

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Light deprivation accelerates recovery from frontal cortical neglect: relation to locomotion and striatal Fos expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

10.1016/S0079-6468(08)70081-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference