Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk (Q35037346)

5 August 2017

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk (English)

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5 August 2017

8

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5 August 2017

5

Jonathan Cooper

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5 August 2017

Gary R Mirams

1

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author name string

Yi Cui

2

1 reference

5 August 2017

Anna Sher

3

1 reference

5 August 2017

Martin Fink

4

1 reference

5 August 2017

Bronagh M Heath

6

1 reference

5 August 2017

Nick C McMahon

7

1 reference

5 August 2017

Denis Noble

9

1 reference

5 August 2017

7 February 2011

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5 August 2017

Cardiovascular Research

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5 August 2017

91

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5 August 2017

1

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5 August 2017

53-61

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A novel computational model of the human ventricular action potential and Ca transient

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Safety and secondary pharmacology: successes, threats, challenges and opportunities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

CellML and associated tools and techniques

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Cardiovascular risks of atypical antipsychotic drug treatment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Torsade de pointes induced by psychotropic drugs and the prevalence of its risk factors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Drugs, QT interval prolongation and ICH E14: the need to get it right

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Cardiac Action and Pacemaker Potentials based on the Hodgkin-Huxley Equations

8 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

8 July 2018

https://api.crossref.org/works/10.1093%2FCVR%2FCVR044

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Antihistamine drug withdrawn by manufacturer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Hay fever drug to be banned by the FDA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

The isolation and characterization of calcium-tolerant myocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112019

Discontinuation of thioridazine. Risks must be balanced

8 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR044

Clinical evaluation of QT/QTc prolongation and proarrhythmic potential for nonantiarrhythmic drugs: the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use E14 guideline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR044

Torsade de pointes in a patient with complex medical and psychiatric conditions receiving low-dose quetiapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR044

The CellML Model Repository

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR044

Chaste: A test-driven approach to software development for biological modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVR044

Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death

21 January 2018

1 reference

12 December 2020

Alternans and spiral breakup in a human ventricular tissue model

1 reference

12 December 2020

From the Food and Drug Administration

1 reference

12 December 2020

Discontinuation of thioridazine. What happened to thioridazine?

1 reference

12 December 2020

Identifiers

DOI

10.1093/CVR/CVR044

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5 August 2017

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5 August 2017

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