Reactive metabolites of phenacetin and acetaminophen: a review (Q35037087)

5 August 2017

2 references

7 November 2019

12 November 2019

Reactive metabolites of phenacetin and acetaminophen: a review (English)

1 reference

5 August 2017

1 reference

7 November 2019

1 reference

7 November 2019

1 reference

12 November 2019

1 reference

J. A. Hinson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6339229

2 October 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6339229

2 October 2023

publication date

1 March 1983

3 references

5 August 2017

7 November 2019

12 November 2019

9

1 reference

full work available at URL

inferred from page(s)

https://doi.org/10.1289/ehp.834971

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6339229

https://europepmc.org/articles/PMC1569121

2 October 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6339229

https://europepmc.org/articles/PMC1569121?pdf=render

2 October 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6339229

https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.834971

2 October 2023

1 reference

https://api.crossref.org/works/10.1289/EHP.834971

Environmental Health Perspectives

2 October 2023

published in

3 references

5 August 2017

7 November 2019

12 November 2019

49

1 reference

5 August 2017

page(s)

71-79

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Liver necrosis from paracetamol

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Acute liver necrosis following overdose of paracetamol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

N-hydroxy-2-acetylaminofluorene sulfotransferase: its probable role in carcinogenesis and in protein-(methion-S-yl) binding in rat liver

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Renal disease due to analgesics. I. Recognition of the problem of analgesic nephropathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Analgesic Abuse and Renal Disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

N-hydroxylation of p-chloroacetanilde in hamsters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Malignancies of the urinary tract and their relation to analgesic abuse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Liver and kidney damage induced by N-hydroxyparacetamol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Kinetic Evidence for Multiple Chemically Reactive Intermediates in the Breakdown of Phenacetin N-O-Glucuronide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Metabolism of [p-18O]-phenacetin: the mechanism of activation of phenacetin to reactive metabolites in hamsters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Tumors of Sprague-Dawley rats induced by long-term feeding of phenacetin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

N-Hydroxylation of phenacetin by hamster liver microsomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569121

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism

8 July 2018

1 reference

12 December 2020

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro

1 reference

12 December 2020

N-hydroxyacetaminophen: A microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen

1 reference

12 December 2020

3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen

1 reference

12 December 2020

The formation of arylating and alkylating metabolites of phenacetin in hamsters and hamster liver microsomes

1 reference

12 December 2020

Acetaminophen-induced hepatotoxicity

1 reference

12 December 2020

Carcinoma of the renal pelvis in renal papillary necrosis

1 reference

12 December 2020

Metabolism of acetanilides and anisoles with rat liver microsomes

1 reference

12 December 2020

N-Hydroxylation of p-acetophenetidide as a factor in nephrotoxicity

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.834971

1 reference

release_4y7gugu5sbhw5ji4eteyfhbuxq

5 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4y7gugu5sbhw5ji4eteyfhbuxq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

1569121

1 reference

5 August 2017

1 reference