Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses (Q35031738)

5 August 2017

title

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses (English)

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5 August 2017

14

Genhong Cheng

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5 August 2017

Eugene J Gillespie

1

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5 August 2017

Chi-Lee C Ho

2

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5 August 2017

Kavitha Balaji

3

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5 August 2017

Daniel L Clemens

4

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5 August 2017

Gang Deng

5

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5 August 2017

Yao E Wang

6

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5 August 2017

Heidi J Elsaesser

7

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5 August 2017

Batcha Tamilselvam

8

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5 August 2017

Amandeep Gargi

9

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5 August 2017

Shandee D Dixon

10

1 reference

5 August 2017

Bryan France

11

1 reference

5 August 2017

Brian T Chamberlain

12

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5 August 2017

Steven R Blanke

13

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5 August 2017

Juan Carlos de la Torre

15

1 reference

5 August 2017

David G Brooks

16

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5 August 2017

Michael E Jung

17

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5 August 2017

John Colicelli

18

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5 August 2017

Robert Damoiseaux

19

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5 August 2017

Kenneth A Bradley

20

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5 August 2017

language of work or name

English

0 references

publication date

4 November 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

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5 August 2017

volume

110

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5 August 2017

issue

50

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5 August 2017

page(s)

E4904-12

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describes a project that uses

5 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3864319/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor

1 reference

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Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi

8 July 2018

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The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Bacterial toxin modulation of the eukaryotic cell cycle: are all cytolethal distending toxins created equally?

8 July 2018

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Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway

8 July 2018

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Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

8 July 2018

1 reference

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O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages

8 July 2018

1 reference

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The biology of the cytolethal distending toxins

8 July 2018

1 reference

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Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition

8 July 2018

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Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

8 July 2018

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Role of endosomes in simian virus 40 entry and infection

8 July 2018

1 reference

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Novel approaches in anti-arenaviral drug development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Inhibition of retrograde transport protects mice from lethal ricin challenge

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

8 July 2018

1 reference

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Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Cellular and systemic effects of anthrax lethal toxin and edema toxin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Francisella tularensis phagosomal escape does not require acidification of the phagosome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Role of endocytosis and cathepsin-mediated activation in Nipah virus entry

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Identification and characterization of small molecules that inhibit intracellular toxin transport

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Amiodarone and bepridil inhibit anthrax toxin entry into host cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Uptake and intracellular fate of Francisella tularensis in human macrophages

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Dynasore, a cell-permeable inhibitor of dynamin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Delivery into cells: lessons learned from plant and bacterial toxins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Rapid lethal effect in rats of a third component found upon fractionating the toxin of Bacillus anthracis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Identification of the cellular receptor for anthrax toxin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Pathogenic trickery: deception of host cell processes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Rab11b is essential for recycling of transferrin to the plasma membrane

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Anthrax protective antigen: prepore-to-pore conversion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Researchers seek new weapon against the flu.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Acidic pH triggers LCMV membrane fusion activity and conformational change in the glycoprotein spike

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Mechanism of lymphocytic choriomeningitis virus entry into cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Anthrax protective antigen forms oligomers during intoxication of mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Diphtheria toxin entry into cells is facilitated by low pH.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Homologous interference of lymphocytic choriomeningitis virus involves a ribavirin-susceptible block in virus replication.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

The pH independence of mammalian retrovirus infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Brefeldin A: insights into the control of membrane traffic and organelle structure

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3864319

Anthrax toxin protective antigen: low-pH-induced hydrophobicity and channel formation in liposomes

25 October 2018

1 reference

12 December 2020

Anthrax lethal factor cleaves the N-terminus of MAPKKS and induces tyrosine/threonine phosphorylation of MAPKS in cultured macrophages

1 reference

12 December 2020

Translocation of full-length Pseudomonas exotoxin from endosomes is driven by ATP hydrolysis but requires prior exposure to acidic pH

1 reference

12 December 2020

pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen

1 reference

12 December 2020

Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1302334110

1 reference

5 August 2017

0 references

1 reference

5 August 2017

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