Structural biology and function of solute transporters: implications for identifying and designing substrates (Q35027925)

5 August 2017

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title

Structural biology and function of solute transporters: implications for identifying and designing substrates (English)

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5 August 2017

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3

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5 August 2017

Peter W Swaan

4

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author name string

Eric Y Zhang

series ordinal

1

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5 August 2017

Gregory T Knipp

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

1 November 2002

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5 August 2017

published in

Drug Metabolism Reviews

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5 August 2017

volume

34

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5 August 2017

issue

4

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5 August 2017

page(s)

709-750

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Bile acid transport systems as pharmaceutical targets

5 August 2017

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Identification of a Mutation in the Ileal Sodium-dependent Bile Acid Transporter Gene That Abolishes Transport Activity

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Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins.

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Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide

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Location of helix III in the lactose permease of Escherichia coli as determined by site-directed thiol cross-linking

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Estimating loop-helix interfaces in a polytopic membrane protein by deletion analysis

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Topology prediction for helical transmembrane proteins at 86% accuracy

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Principles governing amino acid composition of integral membrane proteins: application to topology prediction

21 January 2018

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The role of helix VIII in the lactose permease of Escherichia coli: I. Cys-scanning mutagenesis

21 January 2018

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Membrane topology of the human Na+/glucose cotransporter SGLT1

21 January 2018

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The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain

21 January 2018

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Proximity between Glu126 and Arg144 in the lactose permease of Escherichia coli

21 January 2018

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Proximity of helices VIII (Ala273) and IX (Met299) in the lactose permease of Escherichia coli.

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Dynamics of lactose permease of Escherichia coli determined by site-directed fluorescence labeling.

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Use of site-directed fluorescence labeling to study proximity relationships in the lactose permease of Escherichia coli

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Design of a membrane protein for site-specific proteolysis: properties of engineered factor Xa protease sites in the lactose permease of Escherichia coli

21 January 2018

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Experimental basis for use of peptides as substrates for parenteral nutrition: a review

21 January 2018

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Dipeptides in clinical nutrition

21 January 2018

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A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors.

21 January 2018

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Peptide transporters in the intestine and the kidney

21 January 2018

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Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells

21 January 2018

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Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery

21 January 2018

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Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors

21 January 2018

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Differential Recognition of β-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2

21 January 2018

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Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.

21 January 2018

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21 January 2018

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Structure and function of eukaryotic peptide transporters

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Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1.

21 January 2018

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Clinical pharmacokinetics of the angiotensin converting enzyme inhibitors. A review

21 January 2018

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Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain

21 January 2018

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Association of intestinal peptide transport with a protein related to the cadherin superfamily

21 January 2018

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Partial ileal bypass for hypercholesterolemia. 20- to 26-year follow-up of the first 57 consecutive cases

21 January 2018

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21 January 2018

Bile acid sequestrants

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Lipid Digestion and Absorption

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Intestinal and hepatobiliary disposition of drugs

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

The rabbit ileal lipid-binding protein. Gene cloning and functional expression of the recombinant protein

21 January 2018

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Intestinal absorption of bile acids: paradoxical behaviour of the 14 kDa ileal lipid-binding protein in differential photoaffinity labelling

21 January 2018

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Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

21 January 2018

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

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Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter

21 January 2018

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Conjugated bile acid uptake by Xenopus laevis oocytes induced by microinjection with ileal Poly A+ mRNA.

21 January 2018

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Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Membrane insertion scanning of the human ileal sodium/bile acid co-transporter

21 January 2018

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Reconstitution of bile acid transport in a heterologous cell by cotransfection of transporters for bile acid uptake and efflux

21 January 2018

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Topogenic signals in integral membrane proteins

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

New insights into bile acid transport

21 January 2018

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The continuing importance of bile acids in liver and intestinal disease

21 January 2018

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Properties and biological significance of the ileal bile salt transport system

21 January 2018

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Ileal transport of bile acids conjugated with norleucine and lysine

21 January 2018

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21 January 2018

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21 January 2018

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Absorption of urso- and chenodeoxycholic acid and their taurine and glycine conjugates in rat jejunum, ileum, and colon.

21 January 2018

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Bile acid active and passive ileal transport in the rabbit: effect of luminal stirring.

21 January 2018

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Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat

21 January 2018

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Active and passive bile acid absorption in man. Perfusion studies of the ileum and jejunum

21 January 2018

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Molecular modeling of the intestinal bile acid carrier: a comparative molecular field analysis study

21 January 2018

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Utilizing bile acid carrier mechanisms to enhance liver and small intestine absorption

21 January 2018

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Enhanced transepithelial transport of peptides by conjugation to cholic acid

21 January 2018

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Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21-methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system

21 January 2018

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The effect of tyrosine conjugation on the critical micellar concentration of free and glycine-conjugated bile salts

21 January 2018

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Selectively reduced biliary excretion of cholyldiglycylhistamine but not of cholyltetraglycylhistamine in ethinyl estradiol-treated rats. A possible indicator of increased bile canalicular permeability

21 January 2018

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Inhibition of bile salt absorption by blood-sugar lowering biguanides

21 January 2018

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Progress in predicting human ADME parameters in silico

21 January 2018

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Structure of bacteriorhodopsin at 1.55 A resolution

21 January 2018

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Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin

21 January 2018

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Peptides in human nutrition

21 January 2018

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Acetylcholine receptor channel imaged in the open state

21 January 2018

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Generation of β-globin by sequence-specific proteolysis of a hybrid protein produced in Escherichia coli

21 January 2018

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A novel class of apical sodium co-dependent bile acid transporter inhibitors: the 2,3-disubstituted-4-phenylquinolines

21 January 2018

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Eukaryotic transmembrane solute transport systems.

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21 January 2018

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Two-dimensional crystallization of Escherichia coli lactose permease

21 January 2018

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Membrane topology of the human dipeptide transporter, hPEPT1, determined by epitope insertions

21 January 2018

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The significance of peptides in clinical nutrition

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs

21 January 2018

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Absorption of ACE inhibitors from small intestine and colon

21 January 2018

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Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa

21 January 2018

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Drug transport and targeting. Intestinal transport.

21 January 2018

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Molecular and structural features of the proton-coupled oligopeptide transporter superfamily.

21 January 2018

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Molecular modeling study of structural requirements for the oligopeptide transporter

21 January 2018

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Molecular Determinants of Recognition for the Intestinal Peptide Carrier

21 January 2018

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Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril

21 January 2018

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Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2

21 January 2018

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How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1

21 January 2018

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Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120015692

The hypocholesterolemic action of TA-7552 and its effects on cholesterol metabolism in the rat

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Identification of the 14 kDa bile acid transport protein of rat ileal cytosol as gastrotropin

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Expression and localization of intestinal 15 kDa protein in the rat

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Identification and comparison of bile acid-binding polypeptides in ileal basolateral membrane

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120015692

Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120015692

Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120015692

Bile acid derived HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120015692

Reduction of cardiovascular and thyroxine-suppressing activities of L-T3 by liver targeting with cholic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120015692

Evaluation of the bile acid transporter in enhancing intestinal permeability to renin-inhibitory peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120015692

21 January 2018

Identifiers

DOI

10.1081/DMR-120015692

1 reference

5 August 2017

1 reference