mRNA display: from basic principles to macrocycle drug discovery (Q35025892)

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English	mRNA display: from basic principles to macrocycle drug discovery	scientific article

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Europe PubMed Central

5 August 2017

mRNA display: from basic principles to macrocycle drug discovery (English)

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Europe PubMed Central

5 August 2017

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3

Jack W Szostak

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Europe PubMed Central

5 August 2017

Kristopher Josephson

1

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stated in

Europe PubMed Central

PubMed ID

24157402

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5 August 2017

Alonso Ricardo

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2

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stated in

Europe PubMed Central

5 August 2017

22 October 2013

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Europe PubMed Central

5 August 2017

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Europe PubMed Central

5 August 2017

19

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Europe PubMed Central

5 August 2017

4

1 reference

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Europe PubMed Central

5 August 2017

388-399

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stated in

Europe PubMed Central

5 August 2017

Ribosomal synthesis of unnatural peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Transformation of aminoacyl tRNAs for the in vitro selection of "drug-like" molecules

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

N-methylation of peptides and proteins: an important element for modulating biological functions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Uniform binding of aminoacyl-tRNAs to elongation factor Tu by thermodynamic compensation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Fragment-based approaches in drug discovery and chemical biology

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Inefficient delivery but fast peptide bond formation of unnatural L-aminoacyl-tRNAs in translation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Converting peptides into drug leads by lipidation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Testing physical models of passive membrane permeation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

15 Biosynthetic method for introducing unnatural amino acids site-specifically into proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

A simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Reevaluation of the D-amino acid compatibility with the elongation event in translation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

In vitro selection of multiple libraries created by genetic code reprogramming to discover macrocyclic peptides that antagonize VEGFR2 activity in living cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

RNA-peptide fusions for the in vitro selection of peptides and proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

A novel strategy for in vitro selection of peptide-drug conjugates

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

N-methylation of peptides: a new perspective in medicinal chemistry

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Understanding the sequence specificity of tRNA binding to elongation factor Tu using tRNA mutagenesis.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Polymerization of alpha-hydroxy acids by ribosomes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Phage display for selection of novel binding peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Fluorine in pharmaceuticals: looking beyond intuition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

A general route for post-translational cyclization of mRNA display libraries

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

N-methylated cyclic pentaalanine peptides as template structures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Ribosomal synthesis of dehydroalanine-containing peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Histidine 66 in Escherichia coli elongation factor tu selectively stabilizes aminoacyl-tRNAs.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Intestinal permeability of cyclic peptides: common key backbone motifs identified.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Cell-free translation reconstituted with purified components

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

The biosynthetic logic of polyketide diversity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Effects of cyclic lipodepsipeptide structural modulation on stability, antibacterial activity, and human cell toxicity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Ribosome-catalyzed polyester formation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

A facile strategy for selective incorporation of phosphoserine into histones.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Flexizymes for genetic code reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

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10.1016/J.DRUDIS.2013.10.011

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stated in

Europe PubMed Central

5 August 2017

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Europe PubMed Central

PubMed ID

24157402

retrieved

5 August 2017

mRNA display: from basic principles to macrocycle drug discovery (Q35025892)

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mRNA display: from basic principles to macrocycle drug discovery (Q35025892)

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