Evaluating pharmacokinetic and pharmacodynamic interactions with computational models in supporting cumulative risk assessment (Q35024790)

5 August 2017

3 references

20 August 2019

19 September 2019

25 January 2021

Evaluating pharmacokinetic and pharmacodynamic interactions with computational models in supporting cumulative risk assessment (English)

1 reference

5 August 2017

physiological phenomenon

1 reference

biomedical investigative technique

20 August 2019

1 reference

19 September 2019

1 reference

25 January 2021

1 reference

1 reference

Melvin Andersen

4

0 references

Harvey J Clewell

series ordinal

2

object named as

Harvey Clewell

1 reference

5 August 2017

Yu-Mei Tan

1

1 reference

PubMed ID

21655141

5 August 2017

Jerry Campbell

series ordinal

3

1 reference

5 August 2017

19 May 2011

1 reference

PubMed ID

21655141

5 August 2017

1 May 2011

3 references

20 August 2019

19 September 2019

25 January 2021

18

1 reference

International Journal of Environmental Research and Public Health

inferred from page(s)

published in

4 references

5 August 2017

20 August 2019

19 September 2019

25 January 2021

8

1 reference

5 August 2017

1613-1630

1 reference

5 August 2017

5

1 reference

Creative Commons Attribution 3.0 Unported

5 August 2017

3 references

20 August 2019

19 September 2019

Mechanistic approaches for mixture risk assessments-present capabilities with simple mixtures and future directions

25 January 2021

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Cumulative risk assessment of chemical exposures in urban environments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Physiologically-based pharmacokinetics in drug development and regulatory science

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Extrapolating in vitro metabolic interactions to isolated perfused liver: predictions of metabolic interactions between R-bufuralol, bunitrolol, and debrisoquine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Trichloroethylene risk assessment: a review and commentary

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

The role of biotransformation and bioactivation in toxicity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

The quantitative prediction of CYP-mediated drug interaction by physiologically based pharmacokinetic modeling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Implications of chemical mixtures in public health practice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

A new approach to decoding life: systems biology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Biological monitoring of workers exposed to ethylbenzene and co-exposed to xylene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Metabolism of trichloroethylene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Effect of 18 HR fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Metabolic activation of phosphorothioate pesticides: role of the liver

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Mechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two-stage model of toxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

PB-PK derived metabolic constants, hepatotoxicity, and lethality of BrCCl3 in rats pretreated with chlordecone, phenobarbital, or mirex.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Pivotal Role of Hepatocellular Regeneration in the Ultimate Hepatotoxicity of CCl 4 in Chlordecone-, Mirex-, or Phenobarbital-Pretreated Rats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Potentiation of the hepatotoxicity of carbon tetrachloride following preexposure to chlordecone (Kepone) in the male rat

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment

8 July 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Acute, short-term, and subchronic oral toxicity of 1,1,1-trichloroethane in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Application of physiologically-based pharmacokinetic modeling to investigate the toxicological interaction between chlorpyrifos and parathion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Bayesian calibration of a physiologically based pharmacokinetic/pharmacodynamic model of carbaryl cholinesterase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Potentiation of CCl4 hepatotoxicity and lethality by chlordecone in female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Resiliency to amplification of carbon tetrachloride hepatotoxicity by chlordecone during postnatal development in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3108131

Testing for Additivity at Select Mixture Groups of Interest Based on Statistical Equivalence Testing Methods

25 October 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJERPH8051613

Physiologically based pharmacokinetic estimated metabolic constants and hepatotoxicity of carbon tetrachloride after methanol pretreatment in rats

21 January 2018

1 reference

12 December 2020

Hepatic macromolecular binding following exposure to vinyl chloride

1 reference

12 December 2020

Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation

1 reference

12 December 2020

Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures

1 reference

12 December 2020

Potentiation of carbon tetrachloride hepatotoxicity by inhaled methanol: time course of injury and recovery

1 reference

12 December 2020

Chlordecone-induced potentiation of carbon tetrachloride hepatotoxicity: A morphometric and biochemical study

1 reference

12 December 2020

Chlordecone-induced potentiation of carbon tetrachloride hepatotoxicity: A light and electron microscopic study

1 reference

12 December 2020

In vivo metabolic interactions of benzene and toluene

1 reference

12 December 2020

The importance of measured end-points in demonstrating the occurrence of interactions: a case study with methylchloroform and m-xylene

1 reference

12 December 2020

Influence of oral administration of a quaternary mixture of trihalomethanes on their blood kinetics in the rat

1 reference

12 December 2020

An integrated QSAR-PBPK modelling approach for predicting the inhalation toxicokinetics of mixtures of volatile organic chemicals in the rat

1 reference

12 December 2020

Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJERPH8051613

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference

PubMed ID

21655141