The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody (Q35022247)

5 August 2017

title

The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody (English)

1 reference

chronic renal insufficiency

5 August 2017

main subject

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Regina Goetz

6

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Moosa Mohammadi

object named as

Moosa Mohammadi

7

0 references

Makoto Kuro-o

11

object named as

Makoto Kuro-o

1 reference

5 August 2017

12

Orson W Moe

1 reference

5 August 2017

2

Johanne Pastor

1 reference

5 August 2017

Sarah L Barker

1

1 reference

5 August 2017

Danielle Carranza

3

1 reference

5 August 2017

Henry Quiñones

4

1 reference

5 August 2017

Carolyn Griffith

5

1 reference

5 August 2017

Jianfeng Ye

8

1 reference

5 August 2017

Jianning Zhang

9

1 reference

5 August 2017

Ming Chang Hu

10

1 reference

5 August 2017

Sachdev S Sidhu

13

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5 August 2017

language of work or name

English

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publication date

15 October 2014

1 reference

Nephrology Dialysis Transplantation

5 August 2017

published in

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5 August 2017

volume

30

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5 August 2017

issue

2

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5 August 2017

page(s)

223-233

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Klotho has dual protective effects on cisplatin-induced acute kidney injury

5 August 2017

cites work

1 reference

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8 July 2018

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Renal and extrarenal actions of Klotho

8 July 2018

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A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease

8 July 2018

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8 July 2018

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CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies

8 July 2018

1 reference

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Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease

8 July 2018

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Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein

8 July 2018

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Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease

8 July 2018

1 reference

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The emerging role of Klotho in clinical nephrology

8 July 2018

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Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters

8 July 2018

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Klotho as a potential biomarker and therapy for acute kidney injury

8 July 2018

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Relationship of low-circulating "anti-aging" klotho hormone with disability in activities of daily living among older community-dwelling adults

8 July 2018

1 reference

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8 July 2018

1 reference

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Simplified synthetic antibody libraries

8 July 2018

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Soluble klotho and autosomal dominant polycystic kidney disease

8 July 2018

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Acute kidney injury biomarkers: renal angina and the need for a renal troponin I

8 July 2018

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The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB.

8 July 2018

1 reference

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Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation.

8 July 2018

1 reference

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A roadmap to generate renewable protein binders to the human proteome

8 July 2018

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Plasma klotho and mortality risk in older community-dwelling adults

8 July 2018

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Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice

8 July 2018

1 reference

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Klotho deficiency causes vascular calcification in chronic kidney disease

8 July 2018

1 reference

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Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective

8 July 2018

1 reference

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Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status

8 July 2018

1 reference

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Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats

8 July 2018

1 reference

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Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

8 July 2018

1 reference

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Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

8 July 2018

1 reference

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Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70.

8 July 2018

1 reference

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Klotho is a substrate for alpha-, beta- and gamma-secretase

8 July 2018

1 reference

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Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage

8 July 2018

1 reference

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Crystal structure of full-length KcsA in its closed conformation

8 July 2018

1 reference

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Two-state selection of conformation-specific antibodies

8 July 2018

1 reference

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Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

8 July 2018

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High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries

8 July 2018

1 reference

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Amelioration of progressive renal injury by genetic manipulation of Klotho gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Klotho converts canonical FGF receptor into a specific receptor for FGF23

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Regulation of fibroblast growth factor-23 signaling by klotho

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Suppression of aging in mice by the hormone Klotho

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4309192

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane

8 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Severely reduced production of klotho in human chronic renal failure kidney.

21 January 2018

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https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

The impact of nephrectomy and renal transplantation on serum levels of soluble Klotho protein

21 January 2018

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https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Validation of an immunoassay for soluble Klotho protein: decreased levels in diabetes and increased levels in chronic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Laboratory aspects of circulating α-Klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Fibroblast growth factor 23 and soluble klotho in children with chronic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Klotho reduces apoptosis in experimental ischaemic acute renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Soluble serum Klotho levels in healthy subjects. Comparison of two different immunoassays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Soluble serum Klotho in diabetic nephropathy: Relationship to VEGF-A

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFU291

Circulating levels of soluble α-Klotho in patients with chronic kidney disease

21 January 2018

1 reference

12 December 2020

Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

1 reference

12 December 2020

Effects of cinacalcet treatment on serum soluble Klotho levels in haemodialysis patients with secondary hyperparathyroidism

1 reference

12 December 2020

Measurement of serum soluble Klotho levels in CKD 5D patients: useful tool or dispensable biomarker?

1 reference

12 December 2020

Serum soluble α-klotho in hemodialysis patients

1 reference

12 December 2020

Secreted Klotho and FGF23 in chronic kidney disease Stage 1 to 5: a sequence suggested from a cross-sectional study

1 reference

12 December 2020

Circulating α-klotho levels in CKD and relationship to progression

1 reference

12 December 2020

Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats

1 reference

12 December 2020

Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys

1 reference

12 December 2020

Identifiers

DOI

10.1093/NDT/GFU291

1 reference

5 August 2017

1 reference

5 August 2017

1 reference