Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid (Q35017799)

5 August 2017

Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid (English)

1 reference

5 August 2017

0 references

Chiara Nicolini

1

1 reference

5 August 2017

Younghee Ahn

2

1 reference

5 August 2017

Bernadeta Michalski

3

1 reference

5 August 2017

Jong M Rho

4

1 reference

5 August 2017

Margaret Fahnestock

5

1 reference

5 August 2017

20 January 2015

1 reference

Acta Neuropathologica Communications

5 August 2017

1 reference

5 August 2017

3

1 reference

5 August 2017

3

1 reference

Creative Commons Attribution 4.0 International

5 August 2017

start time

20 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/s40478-015-0184-4

0 references

cites work

Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity

1 reference

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Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism

8 July 2018

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Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits

8 July 2018

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8 July 2018

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Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism

8 July 2018

1 reference

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Deregulated mTOR-mediated translation in intellectual disability

8 July 2018

1 reference

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Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities

8 July 2018

1 reference

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Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs

8 July 2018

1 reference

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Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia

8 July 2018

1 reference

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Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Altering the trajectory of early postnatal cortical development can lead to structural and behavioural features of autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Regulation of local translation at the synapse by BDNF.

8 July 2018

1 reference

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Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

mTOR signaling: at the crossroads of plasticity, memory and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Deregulation of EIF4E: a novel mechanism for autism.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

A synaptic trek to autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

8 July 2018

1 reference

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Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic Acid animal model of autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

The Autistic Neuron: Troubled Translation?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

The intense world syndrome--an alternative hypothesis for autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Discrimination learning and reversal of the conditioned eyeblink reflex in a rodent model of autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Epigenetics of autism spectrum disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Upstream and downstream of mTOR

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

A clinical study of 57 children with fetal anticonvulsant syndromes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Levels of categorization in visual recognition studied using functional magnetic resonance imaging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Linking etiologies in humans and animal models: studies of autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.

8 July 2018

1 reference

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Distribution of glial fibrillary acidic protein in gliosed human white matter

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Unfamiliar Face Recognition in Relatively Able Autistic Children

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Dipropylacetamide in the treatment of manic-depressive psychosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

8 July 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Abnormal fear conditioning and amygdala processing in an animal model of autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Autism and mental retardation: neuropathologic studies performed in four retarded persons with autistic behavior.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

Expression of TrkB subtypes in the adult monkey cerebellar cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40478-015-0184-4

BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Face recognition in human extrastriate cortex.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4307681

Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25627160

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S40478-015-0184-4

1 reference

5 August 2017

1 reference

5 August 2017

1 reference