Prospects for the prevention and reversal of type 1 diabetes mellitus (Q35016963)

5 August 2017

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title

Prospects for the prevention and reversal of type 1 diabetes mellitus (English)

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5 August 2017

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Nikolai Petrovsky

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author name string

Diego Silva

series ordinal

2

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5 August 2017

Desmond A Schatz

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3

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5 August 2017

1 January 2002

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5 August 2017

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5 August 2017

62

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5 August 2017

18

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5 August 2017

2617-2635

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https://scigraph.springernature.com/pub.10.2165/00003495-200262180-00005

5 August 2017

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cites work

Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies

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12 December 2020

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12 December 2020

In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.

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12 December 2020

Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays

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12 December 2020

Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1

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12 December 2020

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

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12 December 2020

Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65).

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12 December 2020

Cyclosporine delays but does not prevent clinical onset in glucose intolerant pre-type 1 diabetic children

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12 December 2020

Melatonin protects against streptozotocin, but not interleukin-1beta-induced damage of rodent pancreatic beta-cells

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12 December 2020

Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT).

1 reference

12 December 2020

Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

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12 December 2020

Cytokines in sera from insulin-dependent diabetic patients at diagnosis

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12 December 2020

Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells

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12 December 2020

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes

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12 December 2020

Effect of adjuvant therapy on development of diabetes in mouse and man.

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12 December 2020

Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol

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12 December 2020

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

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12 December 2020

Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice

1 reference

12 December 2020

Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.

1 reference

12 December 2020

Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines

1 reference

12 December 2020

Enhanced survival of grafts genetically endowed with the ability to block CD2 and B7.

1 reference

12 December 2020

The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom

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12 December 2020

Congenital rubella syndrome as a model for type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies

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12 December 2020

Transmission of porcine endogenous retroviruses in severe combined immunodeficient mice xenotransplanted with fetal porcine pancreatic cells

1 reference

12 December 2020

A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes

1 reference

12 December 2020

Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus

1 reference

12 December 2020

Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved

1 reference

12 December 2020

Association between type 1 diabetes age of onset and HLA among sibling pairs.

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12 December 2020

Vascular cell adhesion molecule-Ig fusion protein selectively targets activated alpha 4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice

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12 December 2020

Autoimmune diabetes: the involvement of benign and malignant autoimmunity

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12 December 2020

Autoimmune diabetes mellitus in the BB rat

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12 December 2020

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

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12 December 2020

Manipulation of pancreatic stem cells for cell replacement therapy

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12 December 2020

The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice.

1 reference

12 December 2020

Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway

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12 December 2020

IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.

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12 December 2020

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients

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12 December 2020

Metabolic and immunological effects of cyclosporin in recently diagnosed type 1 diabetes mellitus

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12 December 2020

Post-transplant diabetes mellitus. The role of immunosuppression

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12 December 2020

Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters

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12 December 2020

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

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12 December 2020

Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes

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12 December 2020

Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277

1 reference

12 December 2020

Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice

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12 December 2020

Administration of silica particles or anti-Lyt2 antibody prevents beta-cell destruction in NOD mice given cyclophosphamide

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12 December 2020

BCG vaccination prevents insulin-dependent diabetes mellitus (IDDM) in NOD mice after disease acceleration with cyclophosphamide

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12 December 2020

Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro

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12 December 2020

Mumps virus infects beta cells in human fetal islet cell cultures upregulating the expression of HLA class I molecules.

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12 December 2020

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats

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12 December 2020

Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis

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12 December 2020

Breeding of a non-obese, diabetic strain of mice

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12 December 2020

Peptide therapy for diabetes in NOD mice

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12 December 2020

Defective suppressor cell generation in juvenile onset diabetes

1 reference

12 December 2020

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile

1 reference

12 December 2020

Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives

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12 December 2020

Evidence for the Viral Aetiology of IDDM

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12 December 2020

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process

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12 December 2020

Prodigiosin blocks T cell activation by inhibiting interleukin-2Ralpha expression and delays progression of autoimmune diabetes and collagen-induced arthritis

1 reference

12 December 2020

Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells

1 reference

12 December 2020

Insulin, pancreatic polypeptide, and glucagon antibodies in insulin-dependent diabetes mellitus

1 reference

12 December 2020

Suppression of autologous mixed leukocyte reaction in type 1 diabetes mellitus by in vivo-activated T lymphocytes

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12 December 2020

Secretion and storage of insulin from a human hepatoma cell line (HUH7-INS).

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12 December 2020

Pancreatic islet-cell damage in children with fatal viral infections

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12 December 2020

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro

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12 December 2020

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus

1 reference

12 December 2020

Association of IDDM and attenuated response of 2',5'-oligoadenylate synthetase to yellow fever vaccine

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12 December 2020

Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent Onset

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12 December 2020

Bone marrow abnormalities in the non-obese diabetic mouse

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12 December 2020

Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2

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12 December 2020

Transplanted MHC class I-deficient nonobese diabetic mouse islets are protected from autoimmune injury in diabetic nonobese recipients

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12 December 2020

Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus

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12 December 2020

HIGH FREQUENCY OF DIABETES MELLITUS IN YOUNG ADULTS WITH CONGENITAL RUBELLA

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12 December 2020

Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus

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12 December 2020

Transient hyperglycemia in childhood: identification of a subgroup with imminent diabetes mellitus

1 reference

12 December 2020

Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases

1 reference

12 December 2020

Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM

1 reference

12 December 2020

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

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12 December 2020

Induction of type I diabetes by interferon-alpha in transgenic mice

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12 December 2020

Interferon expression in the pancreases of patients with type I diabetes

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12 December 2020

Postnatal elimination of transplacentally acquired disease-associated antibodies in infants born to families with type 1 diabetes. The Finnish TRIGR Study Group. Trial to Reduce IDDM in the Genetically at Risk

1 reference

12 December 2020

Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes

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12 December 2020

Diabetes and Coxsackie virus B5 infection

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12 December 2020

Standardization of IVGTT to predict IDDM

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12 December 2020

Using beta-cell growth factors to enhance human pancreatic Islet transplantation

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12 December 2020

Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice

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12 December 2020

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice

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12 December 2020

Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.

1 reference

12 December 2020

Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats

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12 December 2020

A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth

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12 December 2020

Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity.

1 reference

12 December 2020

Evidence of circulating interferon-gamma in newly diagnosed diabetic children

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12 December 2020

Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma

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12 December 2020

Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse

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12 December 2020

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

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12 December 2020

Prevention of type I diabetes in nonobese diabetic mice by late intervention with nonhypercalcemic analogs of 1,25-dihydroxyvitamin D3 in combination with a short induction course of cyclosporin A

1 reference

12 December 2020

Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity

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12 December 2020

Delay of type I diabetes in high risk, first degree relatives by parenteral antigen administration: the Schwabing Insulin Prophylaxis Pilot Trial.

1 reference

12 December 2020

Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion

1 reference

12 December 2020

Autoimmune diabetes as a consequence of locally produced interleukin-2

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12 December 2020

Leukocytes infiltrating the pancreatic islets of nonobese diabetic mice are transformed into inactive exiles by combinational anti-cell adhesion therapy

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12 December 2020

Significant role for Fas in the pathogenesis of autoimmune diabetes.

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12 December 2020

In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas

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12 December 2020

Altered cytokine activity in adjuvant inhibition of autoimmune diabetes

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12 December 2020

Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice

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12 December 2020

Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

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12 December 2020

Coxsackie B4 viruses with the potential to damage beta cells of the islets are present in clinical isolates

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12 December 2020

Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis

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12 December 2020

Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane

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12 December 2020

Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity

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12 December 2020

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation

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12 December 2020

Expression of transporter associated with antigen processing-1 in the endocrine cells of human pancreatic islets: effect of cytokines and evidence of hyperexpression in IDDM.

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12 December 2020

Peptide dose, MHC affinity, and target self-antigen expression are critical for effective immunotherapy of nonobese diabetic mouse prediabetes

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12 December 2020

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

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12 December 2020

Cellular immune response to diverse islet cell antigens in IDDM.

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12 December 2020

Effect of vascular endothelial growth factor on growth and differentiation of pancreatic ductal epithelium

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12 December 2020

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases

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12 December 2020

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

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12 December 2020

Depressed suppressor cell activity in patients with newly diagnosed insulin-dependent diabetes mellitus

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12 December 2020

Infection by human cytomegalovirus and rubella virus of cultured human fetal islets of Langerhans.

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12 December 2020

Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM?

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12 December 2020

Beneficial effect of 1,25 dihydroxyvitamin D3 on cytokine-treated human pancreatic islets.

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12 December 2020

A Bovine Albumin Peptide as a Possible Trigger of Insulin-Dependent Diabetes Mellitus

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12 December 2020

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

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12 December 2020

Effect of bacille Calmette-Guérin vaccination on C-peptide secretion in children newly diagnosed with IDDM.

1 reference

12 December 2020

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

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12 December 2020

Isolation of a virus from the pancreas of a child with diabetic ketoacidosis

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12 December 2020

The immunomodulator Linomide: role in treatment and prevention of autoimmune diabetes mellitus

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12 December 2020

Gamma delta T cells as mediators of mucosal tolerance: the autoimmune diabetes model

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12 December 2020

Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice

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12 December 2020

Expression of GAD65 and islet cell antibody (ICA512) autoantibodies among cytoplasmic ICA+ relatives is associated with eligibility for the Diabetes Prevention Trial-Type 1.

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12 December 2020

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice

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12 December 2020

Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells

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12 December 2020

Defective maturation and function of antigen-presenting cells in type 1 diabetes

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12 December 2020

Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection

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12 December 2020

Detection of coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

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12 December 2020

Tolerance induction with agonist peptides recognized by autoaggressive lymphocytes is transient: therapeutic potential for type 1 diabetes is limited and depends on time-point of administration, choice of epitope and adjuvant

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12 December 2020

Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

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12 December 2020

HLA-DQ-restricted, islet-specific T-cell clones of a type I diabetic patient. T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice

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12 December 2020

Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells

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12 December 2020

Oral insulin and the induction of tolerance in man: reality or fantasy?

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12 December 2020

Combined analysis of IDDM-related autoantibodies in healthy schoolchildren

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12 December 2020

Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease

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12 December 2020

Prevention of overt diabetes and insulitis in NOD mice by a single BCG vaccination

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12 December 2020

Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein

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12 December 2020

Streptococcal preparation (OK-432) inhibits development of type I diabetes in NOD mice

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12 December 2020

Expression of a dominant negative inhibitor of NF-kappaB protects MIN6 beta-cells from cytokine-induced apoptosis

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12 December 2020

Beta-cell reactive T-cell clones from type I diabetes patients are not beta cell specific and recognize multiple antigens

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12 December 2020

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice

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12 December 2020

Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency

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12 December 2020

The Diabetes Prevention Trial-Type 1 diabetes (DPT-1): implementation of screening and staging of relatives. DPT-1 Study Group

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12 December 2020

Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma

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12 December 2020

The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group.

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12 December 2020

Interleukin-1 and beta-cell function: more than one second messenger?

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12 December 2020

Human islet cell transplantation--future prospects

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12 December 2020

Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft

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12 December 2020

Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes

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12 December 2020

Prevention of autoimmune type 1 diabetes via mucosal tolerance: is mucosal autoantigen administration as safe and effective as it should be?

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12 December 2020

Theory and practice of nicotinamide trials in pre-type 1 diabetes

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12 December 2020

Gene therapy for diabetes mellitus

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12 December 2020

Mumps and Coxsackie B3 virus infection of human fetal pancreatic islet-like cell clusters

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12 December 2020

In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis

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12 December 2020

Beta cell apoptosis in T cell-mediated autoimmune diabetes

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12 December 2020

Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells

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12 December 2020

The Artificial Pancreas Symposium: glucose monitoring, insulin delivery, feedback control

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12 December 2020

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

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12 December 2020

Fas ligand-mediated mechanisms are involved in autoimmune destruction of islet beta cells in non-obese diabetic mice

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12 December 2020

Prevention of type I diabetes in NOD mice by adjuvant immunotherapy

1 reference

12 December 2020

Autologous mixed lymphocyte reaction in man. VI. Deficiency of autologous mixed lymphocyte reaction in type I (insulin-dependent) diabetes mellitus

1 reference

12 December 2020

Insulin and islet cell autoantibodies as time-dependent covariates in the development of insulin-dependent diabetes: a prospective study in relatives.

1 reference

12 December 2020

Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage

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12 December 2020

Biohybrid artificial pancreas based on macrocapsule device

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12 December 2020

Effect of Bacillus Calmette-Guerin vaccination on new-onset type 1 diabetes. A randomized clinical study

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12 December 2020

Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers

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12 December 2020

Administering glutamic acid decarboxylase to NOD mice prevents diabetes

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12 December 2020

TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide

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12 December 2020

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies

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12 December 2020

Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives

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12 December 2020

Pancreatic stem cells: building blocks for a better surrogate islet to treat type 1 diabetes

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12 December 2020

10.2165/00003495-200262180-00005

Identifiers

DOI

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Dimensions Publication ID

5 August 2017

1009984193

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release_nrjkdeprurexrhdd5yjjxevvmy

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Fatcat

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24 November 2022

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