TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function (Q35014257)

5 August 2017

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function (English)

1 reference

5 August 2017

0 references

3

Florian Mair

1 reference

5 August 2017

Thorsten Buch

11

0 references

Ari Waisman

Ari Waisman

9

0 references

Werner Müller

Werner Müller

8

0 references

Jürgen Ruland

Jürgen Ruland

5

0 references

Burkhard Becher

10

Burkhard Becher

1 reference

5 August 2017

Anna Sledzińska

1

1 reference

5 August 2017

Saskia Hemmers

2

1 reference

5 August 2017

Oliver Gorka

4

1 reference

5 August 2017

Lynsey Fairbairn

6

1 reference

5 August 2017

Anja Nissler

7

1 reference

5 August 2017

language of work or name

English

0 references

publication date

8 October 2013

1 reference

5 August 2017

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5 August 2017

11

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5 August 2017

10

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5 August 2017

e1001674

1 reference

Creative Commons Attribution 4.0 International

5 August 2017

start time

8 October 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity

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Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

8 July 2018

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TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

8 July 2018

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Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression

8 July 2018

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Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation

8 July 2018

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Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development

8 July 2018

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

8 July 2018

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

8 July 2018

1 reference

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Control of regulatory T cell lineage commitment and maintenance

8 July 2018

1 reference

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iNKT cell development is orchestrated by different branches of TGF-beta signaling

8 July 2018

1 reference

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Generation of mice with a conditional allele for transforming growth factor beta 1 gene

8 July 2018

1 reference

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Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Homeostasis of naive and memory T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

TGF-beta: a master of all T cell trades

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

TGFbeta signalling in control of T-cell-mediated self-reactivity

8 July 2018

1 reference

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T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Transforming growth factor-beta regulation of immune responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Specificity and versatility in tgf-beta signaling through Smads

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

CD69 is an immunoregulatory molecule induced following activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

An essential role for Scurfin in CD4+CD25+ T regulatory cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Rapid generation of inducible mouse mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Control of regulatory T cell development by the transcription factor Foxp3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Role of GITR in activation response of T lymphocytes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Homeostasis of alpha beta TCR+ T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

TGF-beta type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

Survival surgery: removal of the spleen or thymus.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3792861

Excision of the Frt-flanked neo R cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination

25 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001674

T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development

21 January 2018

1 reference

12 December 2020

Inducing and expanding regulatory T cell populations by foreign antigen

1 reference

12 December 2020

Transforming growth factor-beta pathway serves as a primary tumor suppressor in CD8+ T cell tumorigenesis

1 reference

12 December 2020

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

12 December 2020

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse

1 reference

12 December 2020

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

1 reference

12 December 2020

TGF-β puts the brakes on homeostatic proliferation

1 reference

12 December 2020

10.1371/JOURNAL.PBIO.1001674

Identifiers

DOI

1 reference

5 August 2017

1 reference

5 August 2017

1 reference