Probing the carboxyester side chain in controlled deactivation (-)-δ(8)-tetrahydrocannabinols (Q35013538)

5 August 2017

title

Probing the carboxyester side chain in controlled deactivation (-)-δ(8)-tetrahydrocannabinols (English)

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5 August 2017

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Alexandros Makriyannis

16

object named as

Alexandros Makriyannis

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5 August 2017

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JodiAnne T Wood

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5 August 2017

Spyros P Nikas

1

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5 August 2017

Rishi Sharma

2

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5 August 2017

Carol A Paronis

3

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5 August 2017

Shashank Kulkarni

4

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5 August 2017

Ganesh A Thakur

5

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5 August 2017

Dow Hurst

6

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5 August 2017

Roger S Gifford

8

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5 August 2017

Girija Rajarshi

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5 August 2017

Yingpeng Liu

10

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5 August 2017

Jimit Girish Raghav

11

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5 August 2017

Jason Jianxin Guo

12

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5 August 2017

Torbjörn U C Järbe

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5 August 2017

Patricia H Reggio

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Jack Bergman

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5 August 2017

language of work or name

English

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publication date

16 December 2014

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Journal of Medicinal Chemistry

5 August 2017

published in

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5 August 2017

volume

58

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5 August 2017

issue

2

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5 August 2017

page(s)

665-681

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C-ring cannabinoid lactones: a novel cannabinergic chemotype

5 August 2017

cites work

1 reference

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Controlled-deactivation cannabinergic ligands

8 July 2018

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Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists

8 July 2018

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Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2

8 July 2018

1 reference

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Δ(9)-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice

8 July 2018

1 reference

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The emerging role of human esterases

8 July 2018

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The role of the endocannabinoid system in eating disorders: pharmacological implications

8 July 2018

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Therapeutic modulation of cannabinoid lipid signaling: metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist

8 July 2018

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Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1.

8 July 2018

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Role of cannabinoids in the treatment of pain and (painful) spasticity

8 July 2018

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Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.

8 July 2018

1 reference

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Heteroadamantyl cannabinoids

8 July 2018

1 reference

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Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization

8 July 2018

1 reference

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Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality

8 July 2018

1 reference

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Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity

8 July 2018

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The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

8 July 2018

1 reference

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C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2.

8 July 2018

1 reference

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The endocannabinoid system as an emerging target of pharmacotherapy

8 July 2018

1 reference

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The cannabinergic system as a target for anti-inflammatory therapies

8 July 2018

1 reference

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Structural requirements for cannabinoid receptor probes.

8 July 2018

1 reference

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The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Pharmacokinetics and pharmacodynamics of cannabinoids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Cannabinoids in the treatment of glaucoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor

8 July 2018

1 reference

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Cannabinoid receptors and pain

8 July 2018

1 reference

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A historical overview of chemical research on cannabinoids

8 July 2018

1 reference

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Modeling of loops in protein structures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Crystal structure of rhodopsin: A G protein-coupled receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor

8 July 2018

1 reference

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A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2.

8 July 2018

1 reference

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Comparative protein modelling by satisfaction of spatial restraints

8 July 2018

1 reference

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Molecular characterization of a peripheral receptor for cannabinoids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Determination and characterization of a cannabinoid receptor in rat brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

[Bis(2-methoxyethyl)amino]sulfur trifluoride, the Deoxo-Fluor reagent: application toward one-flask transformations of carboxylic acids to amides

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306527

Soft cannabinoid analogues as potential anti-glaucoma agents

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25470070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cannabinoid receptors as therapeutic targets

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25470070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM501165D

1 reference

5 August 2017

1 reference

5 August 2017

1 reference