Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition (Q35012314)

5 August 2017

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title

Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition (English)

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5 August 2017

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Thomas Hermann

1

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PubMed ID

12458079

5 August 2017

language of work or name

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1 September 2002

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5 August 2017

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5 August 2017

84

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5 August 2017

9

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5 August 2017

869-875

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Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes

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1 reference

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RNA as a drug target: chemical, modelling, and evolutionary tools

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RNA and the Small Molecule World

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Targeting RNA with small molecules

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Rational drug design and high-throughput techniques for RNA targets

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RNA as a drug target: methods for biophysical characterization and screening

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Structure of the 30S ribosomal subunit

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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

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The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

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Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

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Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site

1 reference

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Adaptive recognition by nucleic acid aptamers

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Fitting peptides into the RNA world

1 reference

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Current topics in RNA-protein recognition: control of specificity and biological function through induced fit and conformational capture

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Aminoglycoside-RNA interactions

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Modulation of RNA function by aminoglycoside antibiotics

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Saccharide-RNA recognition

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

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Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit

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Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance

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Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA

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Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme

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Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation

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Stitching together RNA tertiary architectures

1 reference

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Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic

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Design of novel antibiotics that bind to the ribosomal acyltransfer site

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An efficient synthesis of mimetics of neamine for RNA recognition

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Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism

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Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production

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Inhibition of the self-cleavage reaction of the human hepatitis delta virus ribozyme by antibiotics

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Antibiotic inhibition of group I ribozyme function

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Inhibition of RNase P RNA cleavage by aminoglycosides

1 reference

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tRNA(Phe) binds aminoglycoside antibiotics

1 reference

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Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12458079