Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions (Q34992139)

5 August 2017

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title

Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions (English)

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5 August 2017

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T M Fong

1

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5 August 2017

S B Heymsfield

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

14 July 2009

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International Journal of Obesity

5 August 2017

published in

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5 August 2017

volume

33

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5 August 2017

issue

9

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5 August 2017

page(s)

947-955

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https://scigraph.springernature.com/pub.10.1038/ijo.2009.132

5 August 2017

exact match

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cites work

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End of the line for cannabinoid receptor 1 as an anti-obesity target?

21 January 2018

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The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells

21 January 2018

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Targeting the endocannabinoid system: to enhance or reduce?

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Endocannabinoid system in food intake and metabolic regulation

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Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents

21 January 2018

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Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

21 January 2018

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A neutral CB1 receptor antagonist reduces weight gain in rat.

21 January 2018

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The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats

21 January 2018

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Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors

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Modulation of transmitter release via presynaptic cannabinoid receptors

21 January 2018

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Endocannabinoid signaling in the brain

21 January 2018

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Analysis of the effect of cannabinoids on GABAergic neurotransmission in the substantia nigra pars reticulata

21 January 2018

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Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Appetite suppression and weight loss after the cannabinoid antagonist SR 141716.

21 January 2018

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Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors.

21 January 2018

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The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake

21 January 2018

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Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice

21 January 2018

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Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice

21 January 2018

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CB1 receptor antagonist AVE1625 affects primarily metabolic parameters independently of reduced food intake in Wistar rats

21 January 2018

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[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

21 January 2018

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Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol

21 January 2018

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Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Autonomic pathways regulating pancreatic exocrine secretion

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Neural connections between the hypothalamus and the liver

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Visceral nerves: vagal and sympathetic innervation

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?

21 January 2018

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Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.

21 January 2018

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Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor

21 January 2018

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Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

21 January 2018

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Transport of iodothyronines from bloodstream to brain: contributions by blood:brain and choroid plexus:cerebrospinal fluid barriers.

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Divergence of melanocortin pathways in the control of food intake and energy expenditure.

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure.

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Activation of the peripheral endocannabinoid system in human obesity

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell.

21 January 2018

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Is rimonabant a safe and effective therapy for sustained weight loss and improved cardiometabolic risk factors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

The pharmacology of human appetite expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Endocannabinoid control of food intake and energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Activity of SR141716 on post-reinforcement pauses in operant responding for sucrose reward in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Delta(9)-THC stimulates food intake in Lewis rats: effects on chow, high-fat and sweet high-fat diets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

Distribution of cannabinoid receptors in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Sympathetic and parasympathetic innervation of adipose tissue: metabolic implications

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Periventricular penetration and disappearance of ICV Tyr-MIF-1, DAMGO, tyrosine, and albumin

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Effects of cannabinoid receptors on skeletal muscle oxidative pathways

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Regulation of appetite: role of leptin in signalling systems for drive and satiety

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https://api.crossref.org/works/10.1038%2FIJO.2009.132

7 January 2021

Identifiers

DOI

10.1038/IJO.2009.132

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Dimensions Publication ID

5 August 2017

1045523134

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