Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities (Q34988817)

5 August 2017

Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities (English)

1 reference

5 August 2017

Tamara Tsalkova

1

1 reference

5 August 2017

Donald K Blumenthal

2

1 reference

5 August 2017

Fang C Mei

3

1 reference

5 August 2017

Mark A White

4

1 reference

5 August 2017

Xiaodong Cheng

5

1 reference

5 August 2017

language of work or name

English

0 references

publication date

24 June 2009

1 reference

Journal of Biological Chemistry

5 August 2017

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5 August 2017

284

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5 August 2017

23644-23651

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5 August 2017

35

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Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Epac and PKA: a tale of two intracellular cAMP receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

HingeMaster: normal mode hinge prediction approach and integration of complementary predictors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Evolution of allostery in the cyclic nucleotide binding module

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Capturing cyclic nucleotides in action: snapshots from crystallographic studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

The cAMP binding domain: an ancient signaling module

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

A family of cAMP-binding proteins that directly activate Rap1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749139

Characterization of the activation of the Rap-specific exchange factor Epac by cyclic nucleotides.

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.024950

Conformational analysis of Epac activation using amide hydrogen/deuterium exchange mass spectrometry

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19553663

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.024950

1 reference

5 August 2017

1 reference

5 August 2017

1 reference