Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability (Q34984467)

5 August 2017

title

Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability (English)

1 reference

5 August 2017

1 reference

Sarah L Donahue

1

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5 August 2017

Qing Lin

series ordinal

2

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5 August 2017

Shang Cao

series ordinal

3

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5 August 2017

H Earl Ruley

series ordinal

4

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5 August 2017

language of work or name

English

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publication date

25 July 2006

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5 August 2017

number of pages

5

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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5 August 2017

volume

103

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5 August 2017

issue

31

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5 August 2017

page(s)

11642-11646

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Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

5 August 2017

cites work

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8 July 2018

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Repair and genetic consequences of endogenous DNA base damage in mammalian cells

8 July 2018

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Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

8 July 2018

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Discovery of mammalian genes that participate in virus infection

8 July 2018

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Environmental and chemical carcinogenesis

8 July 2018

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The epigenetics of cancer etiology

8 July 2018

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Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

8 July 2018

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Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

8 July 2018

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Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene

8 July 2018

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Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells

8 July 2018

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Destructive cycles: the role of genomic instability and adaptation in carcinogenesis

8 July 2018

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Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells

8 July 2018

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A census of human cancer genes

8 July 2018

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Multiple mutations and cancer

8 July 2018

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DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free

8 July 2018

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Mitotic recombination is an important mutational event following oxidative damage

8 July 2018

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Toward maintaining the genome: DNA damage and replication checkpoints

8 July 2018

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Somatic stem cells and the kinetics of mutagenesis and carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Embryonic stem cells and somatic cells differ in mutation frequency and type

8 July 2018

1 reference

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Prevalence of somatic alterations in the colorectal cancer cell genome

8 July 2018

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Stem cells, cancer, and cancer stem cells

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Liver carcinogen aflatoxin B1 as an inducer of mitotic recombination in a human cell line

8 July 2018

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Cancer epidemiology in the last century and the next decade

8 July 2018

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Genome maintenance mechanisms for preventing cancer

8 July 2018

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8 July 2018

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Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

The onset and extent of genomic instability in sporadic colorectal tumor progression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

How many mutations does it take to make a tumor?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Genetic instabilities in human cancers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

The causes and prevention of cancer

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Mitotic recombination in mammalian cells in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Production of homozygous mutant ES cells with a single targeting construct

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

The clonal evolution of tumor cell populations

8 July 2018

1 reference

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How many mutations in a cancer?

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510741103

Chemical carcinogens induce varying patterns of LOH in mouse T-lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510741103

Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510741103

Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510741103

21 January 2018

Aneuploidy and cancer

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510741103

DNA alterations in human aberrant crypt foci and colon cancers by random primed polymerase chain reaction

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544223

Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510741103

Benzo[a]pyrenediol-epoxide induces loss of heterozygosity in Chinese hamster ovary cells heterozygous at the aprt locus

21 January 2018

1 reference

12 December 2020

High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination

1 reference

12 December 2020

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis

1 reference

12 December 2020

Debate surges over the origins of genomic defects in cancer

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0510741103

1 reference

5 August 2017

0 references

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5 August 2017

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