The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces (Q34978500)

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29 January 2020

title

The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces (English)

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29 January 2020

2

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3

Joan-Emma Shea

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29 January 2020

author name string

Nicholas F Dupuis

series ordinal

1

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29 January 2020

Michael T Bowers

series ordinal

4

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29 January 2020

language of work or name

English

0 references

publication date

25 April 2011

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Journal of the American Chemical Society

29 January 2020

published in

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29 January 2020

volume

133

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29 January 2020

page(s)

7240-7243

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29 January 2020

issue

19

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Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

29 January 2020

cites work

1 reference

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On the origins of the weak folding cooperativity of a designed ββα ultrafast protein FSD-1.

8 July 2018

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Stable and metastable states of human amylin in solution.

8 July 2018

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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

8 July 2018

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Unfolded-state dynamics and structure of protein L characterized by simulation and experiment

8 July 2018

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Solution structures of rat amylin peptide: simulation, theory, and experiment

8 July 2018

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Principles governing oligomer formation in amyloidogenic peptides

8 July 2018

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Molecular simulation of ab initio protein folding for a millisecond folder NTL9(1-39)

8 July 2018

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Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor

8 July 2018

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Sequence and crowding effects in the aggregation of a 10-residue fragment derived from islet amyloid polypeptide

8 July 2018

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Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

8 July 2018

1 reference

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A role for helical intermediates in amyloid formation by natively unfolded polypeptides?

8 July 2018

1 reference

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Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants

8 July 2018

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Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

8 July 2018

1 reference

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A test on peptide stability of AMBER force fields with implicit solvation

8 July 2018

1 reference

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Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.

8 July 2018

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Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

8 July 2018

1 reference

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Direct detection of transient alpha-helical states in islet amyloid polypeptide

8 July 2018

1 reference

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Protein misfolding, functional amyloid, and human disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093713

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093713

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

8 July 2018

1 reference

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Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093713

Recovery and purification of highly aggregation-prone disulfide-containing peptides: application to islet amyloid polypeptide

26 October 2018

1 reference

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Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093713

Amyloid Fibril Formation from Full-Length and Fragments of Amylin

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21517093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21517093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21517093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA1081537

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21517093%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21517093%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference