Mitochondrial protein import: two membranes, three translocases (Q34970740)

5 August 2017

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title

Mitochondrial protein import: two membranes, three translocases (English)

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5 August 2017

Nikolaus Pfanner

1

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PubMed ID

12383789

5 August 2017

Nils Wiedemann

series ordinal

2

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5 August 2017

1 August 2002

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Current Opinion in Cell Biology

5 August 2017

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5 August 2017

14

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5 August 2017

4

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5 August 2017

400-411

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Common principles of protein translocation across membranes

5 August 2017

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Protein translocation into mitochondria: the role of TIM complexes

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Opening the door to mitochondrial protein import

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Versatility of the mitochondrial protein import machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The mitochondrial import receptor Tom70: identification of a 25 kDa core domain with a specific binding site for preproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment].

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The preprotein translocation channel of the outer membrane of mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The dimensions of the protein import channels in the outer and inner mitochondrial membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Recognition of preproteins by the isolated TOM complex of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tom5 functionally links mitochondrial preprotein receptors to the general import pore.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Early steps in mitochondrial protein import: receptor functions can be substituted by the membrane insertion activity of apocytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Targeting of the master receptor MOM19 to mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Insertion of MOM22 into the mitochondrial outer membrane strictly depends on surface receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Multistep assembly of the protein import channel of the mitochondrial outer membrane.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Assembly of Tom6 and Tom7 into the TOM core complex of Neurospora crassa.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Biogenesis of Tom40, core component of the TOM complex of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the 'acid chain' hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tim23, a protein import component of the mitochondrial inner membrane, is required for normal activity of the multiple conductance channel, MCC.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Characterization of the mitochondrial inner membrane translocase complex: the Tim23p hydrophobic domain interacts with Tim17p but not with other Tim23p molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Modular structure of the TIM23 preprotein translocase of mitochondria

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tim23 links the inner and outer mitochondrial membranes.

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The Hsp70 peptide-binding domain determines the interaction of the ATPase domain with Tim44 in mitochondria

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Mitochondrial protein import: molecular basis of the ATP-dependent interaction of MtHsp70 with Tim44.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Unfolding of preproteins upon import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Can Hsp70 proteins act as force-generating motors?

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Active unfolding of precursor proteins during mitochondrial protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Mitochondria Unfold Precursor Proteins by Unraveling Them From Their N-termini

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Protein unfolding by the mitochondrial membrane potential

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Cleavage-site motifs in mitochondrial targeting peptides

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The mitochondrial receptor complex: Mom22 is essential for cell viability and directly interacts with preproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Just follow the acid chain

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Self-association and precursor protein binding of Saccharomyces cerevisiae Tom40p, the core component of the protein translocation channel of the mitochondrial outer membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Import of mitochondrial carriers mediated by essential proteins of the intermembrane space

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tim9, a new component of the TIM22.54 translocase in mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The role of the TIM8-13 complex in the import of Tim23 into mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

Peripheral mitochondrial inner membrane protein, Mss2p, required for export of the mitochondrially coded Cox2p C tail in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

The TOM core complex: the general protein import pore of the outer membrane of mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900355-1

7 January 2021

10.1016/S0955-0674(02)00355-1

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12383789