YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease (Q34950066)

5 August 2017

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title

YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease (English)

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5 August 2017

2

Cindy Degerny

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5 August 2017

Kainan Wang

1

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PubMed ID

19234525

5 August 2017

Minghong Xu

series ordinal

3

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PubMed ID

19234525

5 August 2017

Xiang-Jiao Yang

series ordinal

4

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5 August 2017

1 February 2009

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Biochemistry and Cell Biology

5 August 2017

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5 August 2017

87

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5 August 2017

77-91

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5 August 2017

1

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Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome

5 August 2017

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A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

21 January 2018

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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

21 January 2018

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Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

21 January 2018

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Renal cystic diseases: a review.

21 January 2018

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The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions

21 January 2018

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Primary ciliary dyskinesia: current state of the art.

21 January 2018

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YAP1 increases organ size and expands undifferentiated progenitor cells

21 January 2018

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A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells

21 January 2018

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Delineation of a Fat tumor suppressor pathway

21 January 2018

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The regulation of protein function by multisite phosphorylation--a 25 year update

21 January 2018

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Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ

21 January 2018

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Elucidation of a universal size-control mechanism in Drosophila and mammals

21 January 2018

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FGF-2 signaling induces downregulation of TAZ protein in osteoblastic MC3T3-E1 cells

21 January 2018

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The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance

21 January 2018

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Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains

21 January 2018

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Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling

21 January 2018

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A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)

21 January 2018

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Overexpression of Merlin in B16F10 mouse melanoma cells reduces their metastatic activity: role of the cell surface heparan sulfate glycosaminoglycans

21 January 2018

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The localized requirements for a gene affecting segmentation in Drosophila: analysis of larvae mosaic for runt

21 January 2018

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SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

21 January 2018

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The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

21 January 2018

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Magic but treatable? Tumours due to loss of merlin.

21 January 2018

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Tumor suppressor LATS1 is a negative regulator of oncogene YAP

21 January 2018

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The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

21 January 2018

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

21 January 2018

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TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

21 January 2018

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Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor

21 January 2018

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Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

21 January 2018

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Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1

21 January 2018

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Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription

21 January 2018

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

21 January 2018

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Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains

21 January 2018

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Oncogenic potential of the RUNX gene family: 'overview'.

21 January 2018

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Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.

21 January 2018

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

21 January 2018

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TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

21 January 2018

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Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors

21 January 2018

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Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

21 January 2018

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The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary

21 January 2018

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A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ

21 January 2018

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WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

21 January 2018

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Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

21 January 2018

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

21 January 2018

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A crucial role of WW45 in developing epithelial tissues in the mouse

21 January 2018

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TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

21 January 2018

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The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.

21 January 2018

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Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

21 January 2018

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The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members

21 January 2018

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The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling

21 January 2018

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Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

21 January 2018

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RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

21 January 2018

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The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation

21 January 2018

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

21 January 2018

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The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.

21 January 2018

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Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos

21 January 2018

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Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50

21 January 2018

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Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65

21 January 2018

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A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome

21 January 2018

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Transcriptional activity of Pax3 is co-activated by TAZ

21 January 2018

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In vivo regulation of Yorkie phosphorylation and localization.

21 January 2018

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Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)

21 January 2018

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Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

21 January 2018

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Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level

21 January 2018

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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

21 January 2018

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Hippo signaling in organ size control

21 January 2018

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The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

21 January 2018

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TAZ interacts with TTF-1 and regulates expression of surfactant protein-C

21 January 2018

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Molecular messengers of olfaction

21 January 2018

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Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.

21 January 2018

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Filling out the Hippo pathway

21 January 2018

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Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival

21 January 2018

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Reading protein modifications with interaction domains

21 January 2018

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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

21 January 2018

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Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice.

21 January 2018

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Physical interaction with Yes-associated protein enhances p73 transcriptional activity

21 January 2018

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The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

21 January 2018

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Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain

21 January 2018

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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

21 January 2018

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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

21 January 2018

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

21 January 2018

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Molecular pathogenesis of emphysema

21 January 2018

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Identification of TAZ as a binding partner of the polyomavirus T antigens

21 January 2018

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TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex

21 January 2018

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

21 January 2018

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TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

21 January 2018

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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

21 January 2018

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The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

21 January 2018

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Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans

21 January 2018

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

21 January 2018

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The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway

21 January 2018

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Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts

21 January 2018

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Phosphoserine/threonine-binding domains

21 January 2018

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A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

21 January 2018

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Multisite protein modification and intramolecular signaling

21 January 2018

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Lysine acetylation: codified crosstalk with other posttranslational modifications

21 January 2018

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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

21 January 2018

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The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity

21 January 2018

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Yes-associated protein (YAP) functions as a tumor suppressor in breast.

21 January 2018

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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

21 January 2018

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

21 January 2018

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The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals

21 January 2018

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The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

21 January 2018

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

21 January 2018

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TEAD mediates YAP-dependent gene induction and growth control

21 January 2018

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Yes-Associated Protein (YAP) is a critical mediator of c-Jun-dependent apoptosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O08-114

1 reference

5 August 2017

1 reference

PubMed ID

19234525