Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses (Q34948847)

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28 February 2020

title

Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses (English)

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28 February 2020

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4

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Jaranit Kaewkungwal

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8

Sodsai Tovanabutra

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Merlin L Robb

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Nelson L Michael

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Jerome H Kim

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Supachai Rerks-Ngarm

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10

James I Mullins

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Raphael Gottardo

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Peter Gilbert

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5

Allan deCamp

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2

Paul T Edlefsen

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3

Morgane Rolland

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13

Sorachai Nitayaphan

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15

Punnee Pitisuttihum

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12

Nicos Karasavvas

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1

Susan Zolla-Pazner

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Mark S deSouza

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author name string

Constance Williams

7

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Sandra Sharpe-Cohen

9

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Robert J O'Connell

17

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publication date

1 November 2014

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28 February 2020

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28 February 2020

volume

1

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issue

1

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page(s)

37-45

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Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial

28 February 2020

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Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

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Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

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Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial

8 July 2018

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Thermodynamic Signatures of the Antigen Binding Site of mAb 447–52D Targeting the Third Variable Region of HIV-1 gp120

8 July 2018

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Epitope mapping of conformational V2-specific anti-HIV human monoclonal antibodies reveals an immunodominant site in V2.

8 July 2018

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HIV-1 neutralizing antibodies: understanding nature's pathways

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Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees

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Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals

8 July 2018

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Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial

8 July 2018

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Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

8 July 2018

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The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120.

8 July 2018

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8 July 2018

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Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

8 July 2018

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Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials

8 July 2018

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8 July 2018

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Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals

8 July 2018

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A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Structural conservation predominates over sequence variability in the crown of HIV type 1's V3 loop

8 July 2018

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8 July 2018

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8 July 2018

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A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer.

8 July 2018

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Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens

8 July 2018

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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

8 July 2018

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Appreciating HIV type 1 diversity: subtype differences in Env.

8 July 2018

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Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

8 July 2018

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Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1

8 July 2018

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Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia

8 July 2018

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An evolutionary-network model reveals stratified interactions in the V3 loop of the HIV-1 envelope.

8 July 2018

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Autoreactivity in human IgG+ memory B cells

8 July 2018

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Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity

8 July 2018

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Improving on nature: focusing the immune response on the V3 loop.

8 July 2018

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Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection

8 July 2018

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The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.

8 July 2018

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Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D

8 July 2018

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Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.

8 July 2018

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Comparison of competing risks failure time methods and time-independent methods for assessing strain variations in vaccine protection

8 July 2018

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Conserved and exposed epitopes on intact, native, primary human immunodeficiency virus type 1 virions of group M.

8 July 2018

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Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity.

8 July 2018

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Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor

8 July 2018

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CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

8 July 2018

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Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D

8 July 2018

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Complete nucleotide sequences of functional clones of the AIDS virus

8 July 2018

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Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene

8 July 2018

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Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody

8 July 2018

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Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody

8 July 2018

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Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human immunodeficiency virus type 1

8 July 2018

1 reference

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The Analysis of Failure Times in the Presence of Competing Risks

8 July 2018

1 reference

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Passive immunization with a human immunodeficiency virus type 1-neutralizing monoclonal antibody in Hu-PBL-SCID mice: isolation of a neutralization escape variant

8 July 2018

1 reference

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Applying Cox Regression to Competing Risks

26 October 2018

1 reference

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Homology modeling with internal coordinate mechanics: deformation zone mapping and improvements of models via conformational search

26 October 2018

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12 December 2020

Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120

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12 December 2020

Covariability of selected amino acid positions for HIV type 1 subtypes C and B

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12 December 2020

hu-PBL-SCID mice can be protected from HIV-1 infection by passive transfer of monoclonal antibody to the principal neutralizing determinant of envelope gp120

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12 December 2020

10.1016/J.EBIOM.2014.10.022

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25599085%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

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28 February 2020

PubMed publication ID

25599085

1 reference

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