Pharmaceutical approaches to eradication of persistent HIV infection (Q34941973)

5 August 2017

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title

Pharmaceutical approaches to eradication of persistent HIV infection (English)

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eradication of infectious diseases

5 August 2017

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David M Margolis

3

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Nancie M Archin

series ordinal

2

object named as

Nancie M Archin

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5 August 2017

Mary-Catherine Bowman

series ordinal

1

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5 August 2017

11 February 2009

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Expert Reviews in Molecular Medicine

5 August 2017

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5 August 2017

11

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5 August 2017

e6

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Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

5 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

The anatomical basis of intestinal immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Peripheral blood Dendritic cells are not a major reservoir for HIV type 1 in infected individuals on virally suppressive HAART.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Generation of HIV latency during thymopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Eliminating Persistent HIV Infection: Getting to the End of the Rainbow

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

A long-term latent reservoir for HIV-1: discovery and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Stability of the latent reservoir for HIV-1 in patients receiving valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Inhibition of HIV fusion with multivalent gold nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Viral dynamics in HIV-1 infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Retention of antigen on follicular dendritic cells and B lymphocytes through complement-mediated multivalent ligand-receptor interactions: theory and application to HIV treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

HIV-1 dynamics at different time scales under antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Influence of follicular dendritic cells on decay of HIV during antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Prostratin antagonizes HIV latency by activating NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Follicular dendritic cells and human immunodeficiency virus infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Interleukin-7 induces HIV type 1 outgrowth from peripheral resting CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Perils at mucosal front lines for HIV and SIV and their hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1-positive individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

OKT3 and IL-2 treatment for purging of the latent HIV-1 reservoir in vivo results in selective long-lasting CD4+ T cell depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Sodium valproate, an anticonvulsant drug, stimulates human immunodeficiency virus type 1 replication independently of glutathione levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Cyclic polyamides for recognition in the minor groove of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Virus dynamics and drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

The role of mononuclear phagocytes in HTLV-III/LAV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Infection of monocyte/macrophages by human T lymphotropic virus type III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Determining the relative efficacy of highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Correlation between reduction in plasma HIV-1 RNA concentration 1 week after start of antiretroviral treatment and longer-term efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Rapid expression of human immunodeficiency virus following activation of latently infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Tat gets the "green" light on transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Hexamethylbisacetamide remodels the human immunodeficiency virus type 1 (HIV-1) promoter and induces Tat-independent HIV-1 expression but blunts cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Can HIV be Cured? Mechanisms of HIV persistence and strategies to combat it.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Persistent HIV type 1 infection in semen and blood compartments in patients after long-term potent antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

An update on the neuropathology of HIV in the HAART era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Suppression of cerebrospinal fluid HIV burden in antiretroviral naive patients on a potent four-drug antiretroviral regimen

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Viral dynamics in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Decay characteristics of HIV-1-infected compartments during combination therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Reservoirs, sanctuaries, and residual disease: the hiding spots of HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

The challenge of viral reservoirs in HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Importance and detection of virus reservoirs and compartments of HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

The CD16+ Monocyte Subset Is More Permissive to Infection and Preferentially Harbors HIV-1 In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Persistence of replication-competent HIV in the central nervous system despite long-term effective highly active antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Hexamethylene bisacetamide stimulates the expression of human immunodeficiency virus long terminal repeat sequences in rat and human fibroblasts

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Chromatin, gene silencing and HIV latency

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Regulation of HIV-1 latency by T-cell activation.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Differentiation-dependent human immunodeficiency virus long terminal repeat regulatory elements active in human teratocarcinoma cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Hide-and-seek: the challenge of viral persistence in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Plasma HIV-1 RNA dynamics in antiretroviral-naive subjects receiving either triple-nucleoside or efavirenz-containing regimens: ACTG A5166s

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

The regulation of HIV-1 gene expression: the emerging role of chromatin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Host factors regulating post-integration latency of HIV

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399409000970

7 January 2021

10.1017/S1462399409000970

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

19208267