Normal bone marrow signal-transduction profiles: a requisite for enhanced detection of signaling dysregulations in AML. (Q34924495)

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20 January 2020

title

Normal bone marrow signal-transduction profiles: a requisite for enhanced detection of signaling dysregulations in AML (English)

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20 January 2020

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5

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20 January 2020

author name string

James Marvin

1

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20 January 2020

Suchitra Swaminathan

2

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20 January 2020

Geoffrey Kraker

3

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20 January 2020

Amy Chadburn

4

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20 January 2020

Charles Goolsby

6

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20 January 2020

language of work or name

English

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publication date

13 January 2011

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20 January 2020

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20 January 2020

volume

117

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20 January 2020

issue

15

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20 January 2020

page(s)

e120-30

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High-resolution kinetics of cytokine signaling in human CD34/CD117-positive cells in unfractionated bone marrow

20 January 2020

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Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates

8 July 2018

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The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

8 July 2018

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8 July 2018

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Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

8 July 2018

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

8 July 2018

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8 July 2018

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Clinical flow cytometry: a transition in utilization

8 July 2018

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8 July 2018

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The roles of FLT3 in hematopoiesis and leukemia

8 July 2018

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Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry

8 July 2018

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Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor.

8 July 2018

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Negative regulation of the serine/threonine kinase B-Raf by Akt

8 July 2018

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

8 July 2018

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Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor

8 July 2018

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CSF-1 signal transduction

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Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines

8 July 2018

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

8 July 2018

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JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor

8 July 2018

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JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor

8 July 2018

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JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

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8 July 2018

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26 October 2018

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26 October 2018

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26 October 2018

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26 October 2018

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26 October 2018

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Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry

26 October 2018

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Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events

26 October 2018

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Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity.

26 October 2018

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Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells

26 October 2018

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FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

26 October 2018

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Measurement of MAP kinase activation by flow cytometry using phospho-specific antibodies to MEK and ERK: potential for pharmacodynamic monitoring of signal transduction inhibitors.

26 October 2018

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Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome

26 October 2018

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12 December 2020

Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines

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12 December 2020

Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia

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12 December 2020

Aberrant marker expression patterns on the CD34+CD38- stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission

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12 December 2020

Targeted therapy in acute myeloid leukaemia: current status and future directions

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12 December 2020

High frequency of immunophenotype changes in acute myeloid leukemia at relapse: implications for residual disease detection (Cancer and Leukemia Group B Study 8361)

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12 December 2020

Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies

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12 December 2020

Flow cytometric measurement of phosphorylated STAT5 in AML: lack of specific association with FLT3 internal tandem duplications

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12 December 2020

10.1182/BLOOD-2010-10-316026

Identifiers

DOI

1 reference

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20 January 2020

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20 January 2020

PubMed publication ID

21233314

1 reference