Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine (Q34918248)

5 August 2017

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title

Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine (English)

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5 August 2017

2

Satoshi Omura

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5 August 2017

Hirofumi Nakano

1

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5 August 2017

publication date

9 January 2009

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The Journal of Antibiotics

5 August 2017

published in

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5 August 2017

volume

62

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5 August 2017

issue

1

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5 August 2017

page(s)

17-26

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The influence of natural products upon drug discovery

5 August 2017

cites work

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Lessons from natural molecules

21 January 2018

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Drug discovery: a historical perspective

21 January 2018

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Potent and specific inhibitors of protein kinase C of microbial origin

21 January 2018

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Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

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Cellular roles of dna topoisomerases: a molecular perspective

21 January 2018

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Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.

21 January 2018

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A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

21 January 2018

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Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

21 January 2018

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Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

21 January 2018

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

21 January 2018

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Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.

21 January 2018

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The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

21 January 2018

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Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton

21 January 2018

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Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.

21 January 2018

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Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

21 January 2018

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

21 January 2018

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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

21 January 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

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Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

21 January 2018

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Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors

21 January 2018

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Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

21 January 2018

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A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

21 January 2018

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Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

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Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

21 January 2018

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Antimalarial drug discovery: targeting protein kinases

21 January 2018

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Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

21 January 2018

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The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape

21 January 2018

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The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

21 January 2018

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Protein kinases and protein phosphatases in prokaryotes: a genomic perspective.

21 January 2018

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Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy

21 January 2018

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Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication

21 January 2018

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Conserved herpesvirus protein kinases

21 January 2018

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Topoisomerase I inhibitors: camptothecins and beyond

21 January 2018

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

21 January 2018

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Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms

21 January 2018

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Pheophorbide a is a specific probe for ABCG2 function and inhibition.

21 January 2018

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Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.

21 January 2018

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The Serine/Threonine/Tyrosine Phosphoproteome of the Model BacteriumBacillus subtilis

21 January 2018

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Staurosporine, a Potentially Important Gift from a Microorganism

21 January 2018

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7 January 2021

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

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7 January 2021

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation

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7 January 2021

Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus

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7 January 2021

Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccarothrix aerocolonigenes ATCC39243.

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7 January 2021

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

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7 January 2021

K-252a, a potent inhibitor of protein kinase C from microbial origin

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7 January 2021

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

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7 January 2021

Salt form selection and characterization of LY333531 mesylate monohydrate

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7 January 2021

Identifiers

DOI

10.1038/JA.2008.4

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Dimensions Publication ID

5 August 2017

1015192668

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