Selective estrogen receptor modulators: tissue actions and potential for CNS protection. (Q34918018)

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13 December 2019

review article

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title

Selective estrogen receptor modulators: tissue actions and potential for CNS protection (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12353060%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

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M T Littleton-Kearney

1

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13 December 2019

N L Ostrowski

2

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13 December 2019

D A Cox

3

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13 December 2019

M I Rossberg

4

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13 December 2019

P D Hurn

5

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13 December 2019

publication date

1 January 2002

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CNS Neuroscience & Therapeutics

13 December 2019

published in

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13 December 2019

volume

8

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13 December 2019

page(s)

309-330

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13 December 2019

issue

3

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Clinical effects of raloxifene hydrochloride in women

13 December 2019

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12 December 2020

Raloxifene hydrochloride, a selective estrogen receptor modulator: safety assessment of effects on cognitive function and mood in postmenopausal women.

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Selective estrogen receptor modulators: a look ahead

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The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women

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An estrogen receptor basis for raloxifene action in bone

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EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium

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17beta-estradiol reduces stroke injury in estrogen-deficient female animals

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Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism

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12 December 2020

Raloxifene and estradiol benzoate both fully restore hippocampal choline acetyltransferase activity in ovariectomized rats

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12 December 2020

Both raloxifene and estrogen reduce major cardiovascular risk factors in healthy postmenopausal women: A 2-year, placebo-controlled study

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12 December 2020

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12 December 2020

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Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

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Estrogen as a neuroprotectant in stroke

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The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective

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Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain

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A pharmacological review of selective oestrogen receptor modulators

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12 December 2020

Estrogens should not be initiated for the secondary prevention of coronary artery disease: a debate.

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12 December 2020

Effects of estrogen and the selective estrogen receptor modulator raloxifene on markers of inflammation in postmenopausal women

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12 December 2020

Effects of estradiol and raloxifene analog on brain, adrenal and serum allopregnanolone content in fertile and ovariectomized female rats.

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12 December 2020

Neuroprotection by estradiol.

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12 December 2020

Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus

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12 December 2020

LY353381.HCl, a selective estrogen receptor modulator, and experimental stroke

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12 December 2020

Experimental stroke in the female diabetic, db/db, mouse

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12 December 2020

Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action

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12 December 2020

Estrogenic activity of tamoxifen and raloxifene on rat brain AMPA receptors

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12 December 2020

Raloxifene affects brain activation patterns in postmenopausal women during visual encoding

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12 December 2020

Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke

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12 December 2020

Hormone replacement therapy and cognition: systematic review and meta-analysis

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12 December 2020

Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Multiple outcomes of raloxifene evaluation

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12 December 2020

Phase I study of a third-generation selective estrogen receptor modulator, LY353381.HCL, in metastatic breast cancer

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12 December 2020

Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats

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12 December 2020

Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats

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12 December 2020

Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: recent insights and remaining challenges

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12 December 2020

Neuroprotective properties of 17beta-estradiol, progesterone, and raloxifene in MPTP C57Bl/6 mice

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12 December 2020

Estrogen restores postischemic pial microvascular dilation

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12 December 2020

Brain damage, sex hormones and recovery: a new role for progesterone and estrogen?

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12 December 2020

Estrogen-like activity of tamoxifen and raloxifene on NMDA receptor binding and expression of its subunits in rat brain

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12 December 2020

Selective estrogen receptor modulation: the search for an ideal hormonal therapy for breast cancer

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12 December 2020

Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.

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12 December 2020

Randomized, double-blind, placebo-controlled study on effects of raloxifene and hormone replacement therapy on plasma no concentrations, endothelin-1 levels, and endothelium-dependent vasodilation in postmenopausal women

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12 December 2020

A clinical trial of estrogen-replacement therapy after ischemic stroke

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12 December 2020

Neuroendocrine effects of raloxifene hydrochloride in postmenopausal women

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12 December 2020

Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer.

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12 December 2020

Raloxifene enhances nitric oxide release in rat aorta via increasing endothelial nitric oxide mRNA expression

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12 December 2020

What would be the properties of an ideal SERM?

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12 December 2020

Raloxifene: risks and benefits

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12 December 2020

Androgens and estrogens in relation to hot flushes during the menopausal transition

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12 December 2020

Selective estrogen receptor modulator effects in the rat brain

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12 December 2020

Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial

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12 December 2020

Comparative effects of testosterone propionate, oestradiol benzoate, ICI 182,780, tamoxifen and raloxifene on hypothalamic differentiation in the female rat.

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12 December 2020

Raloxifene is associated with less side effects than tamoxifen in women with early breast cancer: a questionnaire study from one physician's practice

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12 December 2020

Estrogen actions throughout the brain

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12 December 2020

Hormone replacement therapy with estradiol valerate and cyproterone acetate: effects on endothelium-dependent vasodilatation and arterial wall compliance

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12 December 2020

Effects of estrogen on memory function in surgically menopausal women

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12 December 2020

Importance of growth hormone for the induction of hepatic low density lipoprotein receptors

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12 December 2020

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.

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12 December 2020

Adjuvant tamoxifen in early-stage breast cancer: effects on intercurrent morbidity and mortality

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12 December 2020

Effects of triiodothyronine, dexamethasone and estradiol-17 beta on GH mRNA in rat pituitary cells in culture as revealed by in situ hybridization

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12 December 2020

Weak estrogenic activity of phenol red in the pituitary gonadotroph: re-evaluation of estrogen and antiestrogen effects.

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12 December 2020

Effects of tamoxifen on spinal bone density in women with breast cancer

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12 December 2020

Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats

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12 December 2020

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women.

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12 December 2020

Inhibitory actions of keoxifene on luteinizing hormone secretion in pituitary gonadotrophs

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12 December 2020

Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats

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12 December 2020

Antagonism of sexual behavior in female rats by ventromedial hypothalamic implants of antiestrogen

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12 December 2020

Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels

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12 December 2020

The effect of tamoxifen on bone mineral content in premenopausal women with breast cancer

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12 December 2020

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12 December 2020

Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.

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12 December 2020

The effect of the antiestrogen tamoxifen on bone mineral density in normal late postmenopausal women

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12 December 2020

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

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12 December 2020

The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats

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12 December 2020

Postischemic cerebral blood flow recovery in the female: effect of 17 beta-estradiol

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12 December 2020

Antiestrogenic properties of raloxifene

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12 December 2020

Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging

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12 December 2020

Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized aged rats

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12 December 2020

Effects of tamoxifen on cardiovascular risk factors in postmenopausal women after 5 years of treatment

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12 December 2020

Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.

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12 December 2020

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions

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12 December 2020

Estrogen use and verbal memory in healthy postmenopausal women.

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12 December 2020

Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat

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12 December 2020

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats

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12 December 2020

Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis

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12 December 2020

Chemoprevention of mammary carcinogenesis in the rat: combined use of raloxifene and 9-cis-retinoic acid.

1 reference

12 December 2020

Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor.

1 reference

12 December 2020

Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women.

1 reference

12 December 2020

Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene

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12 December 2020

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

1 reference

12 December 2020

A controlled trial of raloxifene (LY139481) HCl: impact on bone turnover and serum lipid profile in healthy postmenopausal women

1 reference

12 December 2020

The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat.

1 reference

12 December 2020

The estrogen/neurotrophin connection during neural development: is co-localization of estrogen receptors with the neurotrophins and their receptors biologically relevant?

1 reference

12 December 2020

Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors

1 reference

12 December 2020

Hypocholesterolemic activity of raloxifene (LY139481): pharmacological characterization as a selective estrogen receptor modulator

1 reference

12 December 2020

Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density

1 reference

12 December 2020

Endometrial thickness in tamoxifen-treated patients: correlation with clinical and pathologic findings

1 reference

12 December 2020

Ovarian steroids and the brain: implications for cognition and aging

1 reference

12 December 2020

Estrogen stakes claim to cognition.

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12 December 2020

Identification of a third autonomous activation domain within the human estrogen receptor

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12 December 2020

Effects of estrogen on basal forebrain cholinergic neurons vary as a function of dose and duration of treatment

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12 December 2020

Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription

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12 December 2020

Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites

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12 December 2020

Raloxifene and estrogen: comparative bone-remodeling kinetics

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12 December 2020

Molecular basis of agonism and antagonism in the oestrogen receptor

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12 December 2020

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women

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12 December 2020

Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study.

1 reference

12 December 2020

Selective estrogen receptor modulators: an alternative to hormone replacement therapy

1 reference

12 December 2020

Gender-linked brain injury in experimental stroke.

1 reference

12 December 2020

Gonadal hormones modulate 5-hydroxytryptamine2A receptors: emphasis on the rat frontal cortex.

1 reference

12 December 2020

Tamoxifen and the endometrium: findings of pelvic ultrasound examination

1 reference

12 December 2020

Estrogen therapy in postmenopausal women: effects on cognitive function and dementia

1 reference

12 December 2020

Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women

1 reference

12 December 2020

Basic guide to the mechanisms of antiestrogen action

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12 December 2020

Estrogen-mediated neuroprotection after experimental stroke in male rats

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12 December 2020

Therapeutic potential of selective estrogen receptor modulators.

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12 December 2020

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

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12 December 2020

LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo

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12 December 2020

LY353381 x HCl: an improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34)

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12 December 2020

Cerebral vasodilating capacity during forebrain ischemia: effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase.

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12 December 2020

Raloxifene induces neurite outgrowth in estrogen receptor positive PC12 cells

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12 December 2020

The effect of estrogens and antiestrogens in a rat model for hot flush.

1 reference

12 December 2020

Cellular and molecular basis of estrogen's neuroprotection. Potential relevance for Alzheimer's disease.

1 reference

12 December 2020

The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation

1 reference

12 December 2020

10.1111/J.1527-3458.2002.TB00230.X

Identifiers

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13 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12353060%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

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