Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy (Q34900620)

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English	Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy	scientific article

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scholarly article

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Europe PubMed Central

5 August 2017

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy (English)

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Europe PubMed Central

5 August 2017

hepatocellular carcinoma

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based on heuristic

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Yves-Paul Vandewynckel

1

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31 May 2020

2

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31 May 2020

Xavier Verhelst

6

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31 May 2020

13

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31 May 2020

12

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Bart N Lambrecht

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31 May 2020

Christophe Van Steenkiste

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Christophe Van Steenkiste

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31 May 2020

Hans Van Vlierberghe

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Hans Van Vlierberghe

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31 May 2020

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Chris Vanhove

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31 May 2020

Benedicte Descamps

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Benedicte Descamps

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31 May 2020

Eliene Bogaerts

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Eliene Bogaerts

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31 May 2020

Annelies Paridaens

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Annelies Paridaens

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31 May 2020

Louis Libbrecht

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Louis Libbrecht

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31 May 2020

Sophie Janssens

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Sophie Janssens

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31 May 2020

Anja Van den Bussche

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Anja Van den Bussche

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31 May 2020

author name string

Riet De Rycke

11

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31 May 2020

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publication date

1 October 2014

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5 August 2017

Hepatology international

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31 May 2020

9

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31 May 2020

1

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31 May 2020

93-104

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31 May 2020

https://scigraph.springernature.com/pub.10.1007/s12072-014-9582-0

0 references

The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

The paradox of the unfolded protein response in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Nanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

The unfolded protein response signals through high-order assembly of Ire1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

IRE1 signaling affects cell fate during the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Apoptosis and the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289530

8 July 2018

Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS12072-014-9582-0

21 January 2018

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

1 reference

https://api.crossref.org/works/10.1007%2FS12072-014-9582-0

21 January 2018

Identifiers

10.1007/S12072-014-9582-0

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Europe PubMed Central

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31 May 2020

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31 May 2020

1 reference

Europe PubMed Central

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31 May 2020

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