How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients? (Q34894900)

5 August 2017

4 references

23 March 2019

22 June 2019

11 September 2020

26 September 2020

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients? (English)

1 reference

bacterial infectious disease

5 August 2017

4 references

23 March 2019

22 June 2019

11 September 2020

26 September 2020

1 reference

11 September 2020

Gloria Wong

1

0 references

Fekade Bruck Sime

object named as

Fekade Bruck Sime

series ordinal

2

0 references

Jason A. Roberts

object named as

Jason A Roberts

series ordinal

4

0 references

Jeffrey Lipman

object named as

Jeffrey Lipman

series ordinal

3

0 references

language of work or name

1 reference

28 November 2014

5 references

5 August 2017

23 March 2019

22 June 2019

11 September 2020

26 September 2020

BMC Infectious Diseases

5 references

5 August 2017

23 March 2019

22 June 2019

11 September 2020

26 September 2020

14

1 reference

5 August 2017

288

1 reference

Creative Commons Attribution

5 August 2017

4 references

23 March 2019

22 June 2019

11 September 2020

26 September 2020

0 references

on focus list of Wikimedia project

ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/1471-2334-14-288

0 references

cites work

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Systematic review and meta-analysis of vancomycin-induced nephrotoxicity associated with dosing schedules that maintain troughs between 15 and 20 milligrams per liter

8 July 2018

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Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a pharmacokinetics/pharmacodynamics-based approach

8 July 2018

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Dried blood spot analysis for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis

8 July 2018

1 reference

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Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

8 July 2018

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8 July 2018

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Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Successful long-term treatment of cerebral nocardiosis with unexpectedly low doses of linezolid in an immunocompromised patient receiving complex polytherapy

8 July 2018

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8 July 2018

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Multiple-dose pharmacokinetics of daptomycin during continuous venovenous haemodiafiltration

8 July 2018

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8 July 2018

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Relationship between vancomycin trough concentrations and nephrotoxicity: a prospective multicenter trial

8 July 2018

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Therapeutic drug monitoring of antimicrobials

8 July 2018

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Pharmacokinetics of ciprofloxacin and its penetration into bronchial secretions of mechanically ventilated patients with chronic obstructive pulmonary disease

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Increasing vancomycin serum trough concentrations and incidence of nephrotoxicity

8 July 2018

1 reference

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Tobramycin disposition in ICU patients receiving a once daily regimen: population approach and dosage simulations

8 July 2018

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8 July 2018

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Population pharmacokinetic modeling and optimal sampling strategy for Bayesian estimation of amikacin exposure in critically ill septic patients.

8 July 2018

1 reference

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Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis.

8 July 2018

1 reference

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High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function

8 July 2018

1 reference

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Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

8 July 2018

1 reference

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8 July 2018

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Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction.

8 July 2018

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Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: data from a randomized trial of patients with bacteremia and endocarditis

8 July 2018

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Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction

8 July 2018

1 reference

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8 July 2018

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8 July 2018

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Determination of linezolid in human plasma by high-performance liquid chromatography with ultraviolet detection

8 July 2018

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8 July 2018

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8 July 2018

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The use of extended-interval aminoglycoside dosing strategies for the treatment of moderate-to-severe infections encountered in critically ill surgical patients

8 July 2018

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Clinical outcomes and nephrotoxicity associated with vancomycin trough concentrations during treatment of deep-seated infections

8 July 2018

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Pharmacokinetics of linezolid in septic patients with and without extended dialysis

8 July 2018

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Is vancomycin ototoxicity a significant risk?

8 July 2018

1 reference

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Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists

8 July 2018

1 reference

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Principles of antibacterial dosing in continuous renal replacement therapy

8 July 2018

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Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem

8 July 2018

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The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data

8 July 2018

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8 July 2018

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8 July 2018

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Suboptimal aminoglycoside dosing in critically ill patients

8 July 2018

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Vancomycin ototoxicity: a reevaluation in an era of increasing doses

8 July 2018

1 reference

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Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity

8 July 2018

1 reference

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Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms

8 July 2018

1 reference

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Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infections

8 July 2018

1 reference

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Predictors of mortality for methicillin-resistant Staphylococcus aureus health-care-associated pneumonia: specific evaluation of vancomycin pharmacokinetic indices

8 July 2018

1 reference

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Pharmacodynamics and dosing of aminoglycosides

8 July 2018

1 reference

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In vivo pharmacodynamic activity of daptomycin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Clinical Pharmacokinetics of Linezolid, a Novel Oxazolidinone Antibacterial

8 July 2018

1 reference

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Evaluation of commercial assays for vancomycin and aminoglycosides in serum: a comparison of accuracy and precision based on external quality assessment

8 July 2018

1 reference

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TDM coupled with Bayesian forecasting should be considered an invaluable tool for optimizing vancomycin daily exposure in unstable critically ill patients

8 July 2018

1 reference

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Evaluation of four once-daily aminoglycoside dosing nomograms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Pharmacodynamics of cefepime in patients with Gram-negative infections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Antimicrobial action and pharmacokinetics/pharmacodynamics: the use of AUIC to improve efficacy and avoid resistance.

8 July 2018

1 reference

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Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Therapeutic drug monitoring of tobramycin: once-daily versus twice-daily dosage schedules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Comparison of conventional dosing versus continuous-infusion vancomycin therapy for patients with suspected or documented gram-positive infections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Experience with a once-daily aminoglycoside program administered to 2,184 adult patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Development of resistance during antimicrobial therapy: a review of antibiotic classes and patient characteristics in 173 studies.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

Ciprofloxacin pharmacokinetics in patients with normal and impaired renal function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289211

International study of the prevalence and outcomes of infection in intensive care units

8 July 2018

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DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

21 January 2018

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Ciprofloxacin pharmacokinetics in critically ill patients: a prospective cohort study

21 January 2018

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Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

21 January 2018

1 reference

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Clinical pharmacokinetic/pharmacodynamic profile of linezolid in severely ill intensive care unit patients

21 January 2018

1 reference

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Outcomes of bacteremia due to Pseudomonas aeruginosa with reduced susceptibility to piperacillin-tazobactam: implications on the appropriateness of the resistance breakpoint

21 January 2018

1 reference

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Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

21 January 2018

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First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

21 January 2018

1 reference

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TDM-guided therapy with daptomycin and meropenem in a morbidly obese, critically ill patient.

21 January 2018

1 reference

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Antibacterial therapeutic drug monitoring in cerebrospinal fluid: difficulty in achieving adequate drug concentrations

21 January 2018

1 reference

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Quantification of seven β-lactam antibiotics and two β-lactamase inhibitors in human plasma using a validated UPLC-MS/MS method.

21 January 2018

1 reference

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Pharmacokinetic dosing of aminoglycosides: a controlled trial

21 January 2018

1 reference

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Individualized pharmacokinetic monitoring results in less aminoglycoside-associated nephrotoxicity and fewer associated costs

21 January 2018

1 reference

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Pharmacokinetic variability of extended interval tobramycin in burn patients

21 January 2018

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Elevated vancomycin trough is not associated with nephrotoxicity among inpatient veterans

21 January 2018

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High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity

21 January 2018

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Clinical efficacy of therapeutic drug monitoring in patients receiving vancomycin

21 January 2018

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Effects of prolonged vancomycin administration on methicillin-resistant Staphylococcus aureus (MRSA) in a patient with recurrent bacteraemia.

21 January 2018

1 reference

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Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility

21 January 2018

1 reference

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Monitoring serum vancomycin levels: climbing the mountain because it is there?

21 January 2018

1 reference

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Preferable timing of therapeutic drug monitoring in patients with impaired renal function treated with once-daily administration of vancomycin

21 January 2018

1 reference

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Vancomycin therapeutic drug monitoring: is there a consensus view? The results of a UK National External Quality Assessment Scheme (UK NEQAS) for Antibiotic Assays questionnaire

21 January 2018

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Predictability of vancomycin trough concentrations using seven approaches for estimating pharmacokinetic parameters.

21 January 2018

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Continuous infusion of vancomycin less effective and safe than intermittent infusion, based on pharmacodynamic and pharmacokinetic principles

21 January 2018

1 reference

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Factors associated with inadequate early vancomycin levels in critically ill patients treated with continuous infusion

21 January 2018

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Continuous intravenous administration of vancomycin in medical intensive care unit patients

21 January 2018

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Implementation of a protocol for administration of vancomycin by continuous infusion: pharmacokinetic, pharmacodynamic and toxicological aspects

21 January 2018

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Pharmacokinetics of repeated dosing of linezolid in a hemodialysis patient with chronic renal failure

21 January 2018

1 reference

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Hyperlactacidemia potentially due to linezolid overexposure in a liver transplant recipient.

21 January 2018

1 reference

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Linezolid disposition after standard dosages in critically ill patients undergoing continuous venovenous hemofiltration: a report of 2 cases

21 January 2018

1 reference

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Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis

21 January 2018

1 reference

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Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study

21 January 2018

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Reliable new high-performance liquid chromatographic method for the determination of ciprofloxacin in human serum

21 January 2018

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First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma.

21 January 2018

1 reference

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Simple and sensitive determination of sparfloxacin in pharmaceuticals and biological samples by immunoassay.

21 January 2018

1 reference

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Daptomycin underexposure in a young intravenous drug user who was affected by life-threatening Staphylococcus aureus-complicated skin and soft tissue infection associated with bacteraemia

21 January 2018

1 reference

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Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme

21 January 2018

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Support for higher ciprofloxacin AUC 24/MIC targets in treating Enterobacteriaceae bloodstream infection

21 January 2018

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The relationship between trough concentration of vancomycin and effect on methicillin-resistant Staphylococcus aureus in critically ill patients

21 January 2018

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Comparing 3 methods of monitoring gentamicin concentrations in patients with febrile neutropenia.

26 October 2018

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Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection

26 October 2018

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A rapid high-performance liquid chromatography method to measure linezolid and daptomycin concentrations in human plasma

26 October 2018

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Bioanalysis of tobramycin for therapeutic drug monitoring by solid-phase extraction and capillary zone electrophoresis.

26 October 2018

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Validation of HPLC and UV spectrophotometric methods for the determination of meropenem in pharmaceutical dosage form.

26 October 2018

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Comparison of disk diffusion, Etest and VITEK2 for detection of carbapenemase‐producing Klebsiella pneumoniae with the EUCAST and CLSI breakpoint systems

26 October 2018

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Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis

21 January 2018

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Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock

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Population pharmacokinetics of ceftriaxone and pharmacodynamic considerations in haemodialysed patients

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Which reliable pharmacodynamic breakpoint should be advised for ciprofloxacin monotherapy in the hospital setting? A TDM-based retrospective perspective

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Increased amikacin dosage requirements in burn patients receiving a once-daily regimen

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Effective separation and simultaneous determination of seven fluoroquinolones by capillary electrophoresis with diode-array detector

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A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia

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Mortality in severe sepsis: an inconvenient truth

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12 December 2020

A higher dose of vancomycin in continuous infusion is needed in critically ill patients

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12 December 2020

Simultaneous determination of eight β-lactam antibiotics in human serum by liquid chromatography-tandem mass spectrometry

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12 December 2020

Impact of vancomycin exposure on outcomes in patients with methicillin-resistant Staphylococcus aureus bacteremia: support for consensus guidelines suggested targets

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12 December 2020

Usefulness of monitoring linezolid trough serum concentration in prolonged treatments

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12 December 2020

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

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12 December 2020

What proportion of vancomycin trough levels are drawn too early?: frequency and impact on clinical actions

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12 December 2020

What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance

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12 December 2020

Gentamicin pharmacokinetics during continuous venovenous hemofiltration in critically ill septic patients

1 reference

12 December 2020

A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection

1 reference

12 December 2020

Outcomes of extended-infusion piperacillin-tazobactam: a retrospective analysis of critically ill patients

1 reference

12 December 2020

Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections

1 reference

12 December 2020

Variable disposition of ciprofloxacin in critically ill patients undergoing continuous arteriovenous hemodiafiltration

1 reference

12 December 2020

Fluctuation of the volume of distribution of amikacin and its effect on once-daily dosage and clearance in a seriously ill patient

1 reference

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The pharmacokinetics of intravenous ciprofloxacin 400 mg 12 hourly in patients with severe sepsis: the effect of renal function and intra-abdominal disease

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The pharmacodynamics of aminoglycosides

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Identifiers

DOI

10.1186/1471-2334-14-288

1 reference

PubMed ID

25430961

Dimensions Publication ID

5 August 2017

0 references

1 reference

5 August 2017

1 reference

PubMed ID

25430961