Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial (Q34868983)

5 August 2017

Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial (English)

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5 August 2017

phase II clinical trial

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Oliver Wirths

10

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Jens Wiltfang

Jens Wiltfang

8

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Peter Falkai

Peter Falkai

5

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Gerd Multhaup

7

Gerd Multhaup

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5 August 2017

Thomas Schneider-Axmann

4

Thomas Schneider-Axmann

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5 August 2017

Holger Kessler

1

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5 August 2017

Frank-Gerald Pajonk

2

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5 August 2017

Daniela Bach

3

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Wolfgang Herrmann

6

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Stephanie Schäfer

9

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5 August 2017

Thomas A Bayer

11

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5 August 2017

30 October 2008

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Journal of Neural Transmission

5 August 2017

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5 August 2017

115

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12

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5 August 2017

1651-1659

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https://scigraph.springernature.com/pub.10.1007/s00702-008-0136-2

5 August 2017

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cites work

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00702-008-0136-2

Elevation of serum copper levels in Alzheimer's disease.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00702-008-0136-2

Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00702-008-0136-2

Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

12 December 2020

Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport

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12 December 2020

Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.

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12 December 2020

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

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12 December 2020

Copper perturbation in 2 monozygotic twins discordant for degree of cognitive impairment.

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12 December 2020

[The role of copper in the pathophysiology of Alzheimer's disease].

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12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

Copper, iron and zinc in Alzheimer's disease senile plaques.

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12 December 2020

The metallobiology of Alzheimer's disease

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12 December 2020

Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease.

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12 December 2020

Lipid peroxidation and free radical scavengers in Alzheimer's disease

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

The beta A4 amyloid precursor protein binding to copper.

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12 December 2020

Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease.

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12 December 2020

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

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12 December 2020

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

1 reference

12 December 2020

Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels

1 reference

12 December 2020

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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12 December 2020

In vivo reduction of amyloid-beta by a mutant copper transporter

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12 December 2020

CSF markers for Alzheimer's disease: Total tau, phospho-tau and Aβ42

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12 December 2020

Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies.

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12 December 2020

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

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12 December 2020

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

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12 December 2020

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

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12 December 2020

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

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12 December 2020

Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

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12 December 2020

Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

1 reference

12 December 2020

Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau.

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12 December 2020

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

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12 December 2020

Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

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12 December 2020

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

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12 December 2020

10.1007/S00702-008-0136-2

Identifiers

DOI

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5 August 2017

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