Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation (Q34818743)

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English	Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation	scientific article

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scholarly article

1 reference

Europe PubMed Central

4 August 2017

Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation (English)

1 reference

Europe PubMed Central

4 August 2017

Zeynep H Gümüs

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author name string

Chiung-Wen Chang

1

1 reference

Europe PubMed Central

4 August 2017

Ethan Poteet

2

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Europe PubMed Central

4 August 2017

John A Schetz

3

1 reference

Europe PubMed Central

4 August 2017

Zeynep H Gümüş

4

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Europe PubMed Central

4 August 2017

Harel Weinstein

5

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Europe PubMed Central

4 August 2017

publication date

13 August 2008

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Europe PubMed Central

4 August 2017

number of pages

13

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Neuropharmacology

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Europe PubMed Central

4 August 2017

56 Suppl 1

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Europe PubMed Central

4 August 2017

213-225

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Europe PubMed Central

4 August 2017

Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs

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8 July 2018

Identification of a serotonin/glutamate receptor complex implicated in psychosis

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Protein diffusion on charged membranes: a dynamic mean-field model describes time evolution and lipid reorganization.

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Universally sloppy parameter sensitivities in systems biology models

1 reference

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8 July 2018

Activation of G protein-coupled receptors

1 reference

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8 July 2018

Conformational complexity of G-protein-coupled receptors

1 reference

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8 July 2018

Modeling activated states of GPCRs: the rhodopsin template

1 reference

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Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer.

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Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity

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1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists

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Applying computational modeling to drug discovery and development

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Bioengineering and systems biology

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

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Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors

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8 July 2018

Cell-signalling dynamics in time and space

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A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

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Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation

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Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling

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Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

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8 July 2018

Modeling of signal-response cascades using decision tree analysis.

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8 July 2018

Quantitative analysis of signaling networks.

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8 July 2018

Sef is a spatial regulator for Ras/MAP kinase signaling

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Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

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8 July 2018

Quantitative cell biology with the Virtual Cell

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8 July 2018

Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

1 reference

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8 July 2018

Signaling life and death in the thymus: timing is everything

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8 July 2018

Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy.

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8 July 2018

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

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8 July 2018

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

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8 July 2018

MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network

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Computational cell biology: spatiotemporal simulation of cellular events

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Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

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8 July 2018

Molecular psychology: roles for the ERK MAP kinase cascade in memory

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8 July 2018

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

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8 July 2018

KSR: a MAPK scaffold of the Ras pathway?

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8 July 2018

Mammalian MAP kinase signalling cascades

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8 July 2018

Serotonin and Hallucinogens

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Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells

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8 July 2018

Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis

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Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism

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The human 5-HT1A receptor: comparison of its binding properties in transfected cells and cortical tissue

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High-affinity agonist binding is not sufficient for agonist efficacy at 5-hydroxytryptamine2A receptors: evidence in favor of a modified ternary complex model

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8 July 2018

KSR modulates signal propagation within the MAPK cascade

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8 July 2018

Ultrasensitivity in the mitogen-activated protein kinase cascade

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Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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8 July 2018

The two-state model of receptor activation

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Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro

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G proteins: transducers of receptor-generated signals

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Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis

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Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.

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8 July 2018

Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis

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8 July 2018

Enhanced activation of Akt and extracellular-regulated kinase pathways by simultaneous occupancy of Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT7A receptors in PC12 cells

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26 October 2018

Quantitative information management for the biochemical computation of cellular networks.

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26 October 2018

Spatial Distribution of Calcium Entry Evoked by Single Action Potentials within the Presynaptic Active Zone.

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26 October 2018

ERKs regulate PKC-dependent synaptic depression and declustering of glutamate receptors in cerebellar Purkinje cells

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26 October 2018

ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway

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26 October 2018

Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors

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26 October 2018

Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathway.

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26 October 2018

Mathematical models of protein kinase signal transduction.

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26 October 2018

Efficient coupling of 5-HT1a receptors to the phospholipase C pathway in Xenopus oocytes

1 reference

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26 October 2018

Quantification of information transfer via cellular signal transduction pathways.

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26 October 2018

Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades

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12 December 2020

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Agonist/antagonist interactions with cloned human 5-HT1A receptors: variations in intrinsic activity studied in transfected HeLa cells

1 reference

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12 December 2020

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Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762202

12 December 2020

based on heuristic

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5-hydroxytryptamine2C receptor activation inhibits 5-hydroxytryptamine1B-like receptor function via arachidonic acid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762202

12 December 2020

based on heuristic

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Serotonin activates the mitogen-activated protein kinase pathway in vascular smooth muscle: use of the mitogen-activated protein kinase kinase inhibitor PD098059

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https://pubmed.ncbi.nlm.nih.gov/18762202

12 December 2020

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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762202

12 December 2020

based on heuristic

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Prediction and validation of the distinct dynamics of transient and sustained ERK activation

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https://pubmed.ncbi.nlm.nih.gov/18762202

12 December 2020

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Identifiers

10.1016/J.NEUROPHARM.2008.07.049

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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