Pharmacokinetically guided phase 1 trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors. (Q34817156)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21127194%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Pharmacokinetically guided phase 1 trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors (English)

1 reference

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17 January 2020

main subject

phase I clinical trial

0 references

author

Frank Balis

13

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17 January 2020

author name string

R Bagatell

1

1 reference

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17 January 2020

C E Herzog

2

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17 January 2020

T M Trippett

3

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17 January 2020

J F Grippo

4

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17 January 2020

G Cirrincione-Dall

5

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17 January 2020

E Fox

6

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17 January 2020

M Macy

7

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17 January 2020

J Bish

8

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17 January 2020

P Whitcomb

9

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17 January 2020

A Aikin

10

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17 January 2020

G Wright

11

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17 January 2020

S Yurasov

12

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17 January 2020

L Gore

14

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17 January 2020

language of work or name

English

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publication date

2 December 2010

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17 January 2020

published in

Clinical Cancer Research

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17 January 2020

volume

17

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17 January 2020

issue

3

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17 January 2020

page(s)

611-619

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Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1.

17 January 2020

cites work

1 reference

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Bcl-2 and M-Myc coexpression increases IGF-IR and features of malignant growth in neuroblastoma cell lines

8 July 2018

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

8 July 2018

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Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor.

8 July 2018

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Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

8 July 2018

1 reference

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A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors.

8 July 2018

1 reference

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Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors

26 October 2018

1 reference

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Blastemal expression of type I insulin-like growth factor receptor in Wilms' tumors is driven by increased copy number and correlates with relapse.

26 October 2018

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Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells

26 October 2018

1 reference

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Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice

26 October 2018

1 reference

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Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

26 October 2018

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In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2

26 October 2018

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12 December 2020

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target

1 reference

12 December 2020

Expression of a kinase-deficient IGF-I-R suppresses tumorigenicity of rhabdomyosarcoma cells constitutively expressing a wild type IGF-I-R

1 reference

12 December 2020

Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice

1 reference

12 December 2020

10.1158/1078-0432.CCR-10-1731

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21127194%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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17 January 2020

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