Chaperones and aging: role in neurodegeneration and in other civilizational diseases (Q34815474)

4 August 2017

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title

Chaperones and aging: role in neurodegeneration and in other civilizational diseases (English)

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4 August 2017

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Csaba Söti

1

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PubMed ID

12213225

4 August 2017

Péter Csermely

series ordinal

2

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4 August 2017

1 December 2002

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Neurochemistry International

4 August 2017

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4 August 2017

41

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4 August 2017

6

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4 August 2017

383-389

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Folding of prion protein to its native alpha-helical conformation is under kinetic control

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

The Hsp70 and Hsp60 chaperone machines

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer's disease brains.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Proteins, RNAs and chaperones in enzyme evolution: a folding perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Chaperone overload is a possible contributor to 'civilization diseases'.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Chaperone-supervised conversion of prion protein to its protease-resistant form

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Age-dependent changes of protein structure. The properties of young and old rabbit aldolase are restored after reversible denaturation

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Human olfactory receptor neurons express heat shock protein 70: age-related trends.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Caloric restriction improves thermotolerance and reduces hyperthermia-induced cellular damage in old rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Expression of heat shock proteins in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Non-enzymic post-translational modification of proteins in aging. A review

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Molecular chaperones in cellular protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Small heat shock proteins, the cytoskeleton, and inclusion body formation

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

An in vitro model for the study of microglia-induced neurodegeneration: involvement of nitric oxide and tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

1 reference

7 January 2021

Therapeutic opportunities in polyglutamine disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Cell death mechanisms in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Differential effects of exercise and heat stress on liver HSP70 accumulation with aging

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

The glucose-regulated proteins: stress induction and clinical applications

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Expression and function of heat shock protein 47: a collagen-specific molecular chaperone in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Roles of molecular chaperones in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Macromolecular compartmentation and channeling.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

New insights into the ATP-dependent Clp protease: Escherichia coli and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Shattuck lecture--neurodegenerative diseases and prions

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Heat-labile isozymes of isocitrate lyase from aging Turbatrix aceti

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Increased expression of heat-shock protein 27 kDa in Alzheimer disease: a preliminary study

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Hsp90: chaperoning signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Impaired gene transcription and nuclear protein kinase C activation in the brain and liver of aged rats

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Hsp90 as a capacitor for morphological evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Stabilization and the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Brain t-complex polypeptide 1 (TCP- 1) related to its natural substrate beta1 tubulin is decreased in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Molecular chaperones and the aging process

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Chaperonin-mediated protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Solute and macromolecule diffusion in cellular aqueous compartments

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Regional distribution of Hsp70 in the CNS of young and old food-restricted rats following hyperthermia

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Mechanism of prion loss after Hsp104 inactivation in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Nonenzymatic Deamidation of Asparaginyl and Glutaminyl Residues in Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Hsp90: a specialized but essential protein-folding tool

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

Reversal of age-related effects in rat muscle phosphoglycerate kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900043-8

7 January 2021

10.1016/S0197-0186(02)00043-8

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12213225