Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity (Q34810016)

4 August 2017

title

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity (English)

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4 August 2017

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12

Karen E Pollok

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4 August 2017

8

David R Jones

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4 August 2017

1

Shanbao Cai

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4 August 2017

5

Beth E Juliar

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4 August 2017

6

Anthony L Sinn

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4 August 2017

10

Arthur R Baluyut

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4 August 2017

Haiyan Wang

2

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4 August 2017

Barbara Bailey

3

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4 August 2017

Aaron Ernstberger

4

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4 August 2017

Rebecca J Chan

7

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4 August 2017

Lindsey D Mayo

9

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4 August 2017

W Scott Goebel

11

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4 August 2017

language of work or name

English

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publication date

12 April 2011

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4 August 2017

published in

Clinical Cancer Research

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4 August 2017

volume

17

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4 August 2017

issue

8

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4 August 2017

page(s)

2195-2206

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The assessment of human erythroid output in NOD/SCID mice reconstituted with human hematopoietic stem cells

4 August 2017

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

8 July 2018

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8 July 2018

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Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

8 July 2018

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8 July 2018

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Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

8 July 2018

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8 July 2018

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Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma

8 July 2018

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Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests

8 July 2018

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Preferential proliferation of murine colony-forming units in culture in a chemically defined condition with a macrophage colony-stimulating factor-negative stromal cell clone

8 July 2018

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Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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28 July 2018

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26 October 2018

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26 October 2018

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A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay

26 October 2018

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26 October 2018

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Development of a human adaptive immune system in cord blood cell-transplanted mice

26 October 2018

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Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea

26 October 2018

1 reference

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Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics

26 October 2018

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Down-regulation of DNA repair in human CD34(+) progenitor cells corresponds to increased drug sensitivity and apoptotic response

26 October 2018

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Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.

26 October 2018

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Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.

26 October 2018

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Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.

26 October 2018

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Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors

26 October 2018

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12 December 2020

Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice

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12 December 2020

Human allogeneic stem cell maintenance and differentiation in a long-term multilineage SCID-hu graft

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12 December 2020

Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model

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12 December 2020

Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro

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12 December 2020

10.1158/1078-0432.CCR-10-1959

Identifiers

DOI

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4 August 2017

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4 August 2017

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