Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness (Q34807169)

4 August 2017

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title

Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness (English)

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4 August 2017

Sabata Pierno

2

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Antonella Liantonio

object named as

Antonella Liantonio

series ordinal

3

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Annamaria De Luca

object named as

Annamaria De Luca

series ordinal

1

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Diana Conte Camerino

object named as

Diana Conte Camerino

series ordinal

4

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publication date

1 October 2002

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4 August 2017

Neuromuscular Disorders

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4 August 2017

12 Suppl 1

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4 August 2017

S142-6

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Dystrophin-glycoprotein complex: its role in the molecular pathogenesis of muscular dystrophies.

4 August 2017

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https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Molecular pathophysiology and targeted therapeutics for muscular dystrophy

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https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Calcium homeostasis in dystrophic muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

How calcium influx through calcium leak channels is responsible for the elevated levels of calcium-dependent proteolysis in dystrophic myotubes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Myogenic stem cells for the therapy of primary myopathies: wishful thinking or therapeutic perspective?

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Expression of full-length utrophin prevents muscular dystrophy in mdx mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Gene therapy. Safer and virus-free?

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Therapeutic possibilities in muscular dystrophy: the hope versus the hype

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https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

New therapies in muscular dystrophies.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Cross-talk between pro-inflammatory transcription factors and glucocorticoids.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Deflazacort increases laminin expression and myogenic repair, and induces early persistent functional gain in mdx mouse muscular dystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Regulation of cytosolic calcium in skeletal muscle cells of the mdx mouse under conditions of stress

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

A randomized efficacy and safety trial of oxandrolone in the treatment of Duchenne dystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Elevated subsarcolemmal Ca2+ in mdx mouse skeletal muscle fibers detected with Ca2+-activated K+ channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Alteration in calcium handling at the subcellular level in mdx myotubes.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Calcium currents and transients in co-cultured contracting normal and Duchenne muscular dystrophy human myotubes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Adaptations in myosin heavy chain expression and contractile function in dystrophic mouse diaphragm

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Role of nitric oxide in the pathogenesis of muscular dystrophies: a "two hit" hypothesis of the cause of muscle necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Do immune cells promote the pathology of dystrophin-deficient myopathies?

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Muscle degeneration without mechanical injury in sarcoglycan deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Functional regeneration in the hindlimb skeletal muscle of the mdx mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Higher content of insulin-like growth factor-I in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Contractile function and low-intensity exercise effects of old dystrophic (mdx) mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Evidence ofmdx mouse skeletal muscle fragility in vivo by eccentric running exercise

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Exercise induces myonuclear ubiquitination and apoptosis in dystrophin-deficient muscle of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Pre-clinical screening of drugs using the mdx mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Aging-associated down-regulation of ClC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Skeletal muscle disuse induces fibre type-dependent enhancement of Na(+) channel expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Altered pathological progression of diaphragm and quadriceps muscle in TNF-deficient, dystrophin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

Insulin-like growth factor-I stimulates dephosphorylation of ikappa B through the serine phosphatase calcineurin (protein phosphatase 2B)

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

A "dystrophic" variant of autosomal recessive myotonia congenita caused by novel mutations in the CLCN1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0960-8966%2802%2900100-1

7 January 2021

10.1016/S0960-8966(02)00100-1

Identifiers

DOI

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4 August 2017

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PubMed ID

12206808