Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics (Q34793489)

4 August 2017

title

Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics (English)

1 reference

4 August 2017

Dongxiao Sun

1

1 reference

4 August 2017

Gang Chen

2

1 reference

4 August 2017

Ryan W Dellinger

3

1 reference

4 August 2017

Arun K Sharma

4

1 reference

4 August 2017

Philip Lazarus

5

1 reference

4 August 2017

publication date

1 October 2010

1 reference

Pharmacogenetics and Genomics

4 August 2017

published in

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4 August 2017

volume

20

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4 August 2017

issue

10

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4 August 2017

page(s)

575-585

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Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors

4 August 2017

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1 reference

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Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer

8 July 2018

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8 July 2018

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Identification of the aromatase inhibitors anastrozole and exemestane in human urine using liquid chromatography/tandem mass spectrometry

8 July 2018

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8 July 2018

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Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes

8 July 2018

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Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer.

8 July 2018

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8 July 2018

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Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8

8 July 2018

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Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue

8 July 2018

1 reference

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Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women

8 July 2018

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Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.

8 July 2018

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A liquid chromatography-tandem mass spectrometry method for the simultaneous determination of exemestane and its metabolite 17-dihydroexemestane in human plasma.

26 October 2018

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Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10.

26 October 2018

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Gene expression of 17beta-estradiol-metabolizing isozymes: comparison of normal human mammary gland to normal human liver and to cultured human breast adenocarcinoma cells

26 October 2018

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Pharmacokinetics and tolerability of exemestane in combination with raloxifene in postmenopausal women with a history of breast cancer

26 October 2018

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Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study.

26 October 2018

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The effects of degree of hepatic or renal impairment on the pharmacokinetics of exemestane in postmenopausal women

26 October 2018

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Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes

26 October 2018

1 reference

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Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076703

A general assay for UDPglucuronosyltransferase activity using polar amino-cyano stationary phase HPLC and UDP[U-14C]glucuronic acid.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076703

Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione)

26 October 2018

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12 December 2020

Risk of endometrial cancer after tamoxifen treatment of breast cancer

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12 December 2020

Adjuvant tamoxifen therapy for early stage breast cancer and second primary malignancies. Stockholm Breast Cancer Study Group

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12 December 2020

Pharmacological profiles of exemestane and formestane, steroidal aromatase inhibitors used for treatment of postmenopausal breast cancer

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12 December 2020

Tamoxifen in the treatment of breast cancer

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12 December 2020

Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17

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12 December 2020

Five Years of Letrozole Compared With Tamoxifen As Initial Adjuvant Therapy for Postmenopausal Women With Endocrine-Responsive Early Breast Cancer: Update of Study BIG 1-98

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12 December 2020

Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15

1 reference

12 December 2020

10.1097/FPC.0B013E32833B04AF

Identifiers

DOI

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4 August 2017

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4 August 2017

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