Disulfide-reduced ALS variants of Cu, Zn superoxide dismutase exhibit increased populations of unfolded species (Q34788369)

4 August 2017

title

Disulfide-reduced ALS variants of Cu, Zn superoxide dismutase exhibit increased populations of unfolded species (English)

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amyotrophic lateral sclerosis

4 August 2017

main subject

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Can Kayatekin

1

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4 August 2017

Jill A Zitzewitz

series ordinal

2

1 reference

4 August 2017

C Robert Matthews

series ordinal

3

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4 August 2017

language of work or name

English

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publication date

23 February 2010

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Journal of Molecular Biology

4 August 2017

published in

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4 August 2017

volume

398

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4 August 2017

issue

2

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4 August 2017

page(s)

320-331

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Metal-free ALS variants of dimeric human Cu,Zn-superoxide dismutase have enhanced populations of monomeric species

4 August 2017

cites work

1 reference

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Folding of Cu/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: parallels to precursors in amyloid disease

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Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein folding

8 July 2018

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Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

8 July 2018

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The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis

8 July 2018

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8 July 2018

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Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: decreased stability of the apo state

8 July 2018

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8 July 2018

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Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

8 July 2018

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8 July 2018

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

8 July 2018

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8 July 2018

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

8 July 2018

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.

8 July 2018

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Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase

26 October 2018

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Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution

26 October 2018

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Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.

26 October 2018

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Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

26 October 2018

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Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

26 October 2018

1 reference

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Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria.

26 October 2018

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Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase

26 October 2018

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Multistate equilibrium unfolding of Escherichia coli dihydrofolate reductase: thermodynamic and spectroscopic description of the native, intermediate, and unfolded ensembles

26 October 2018

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12 December 2020

Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes

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12 December 2020

A spectroscopic characterization of a monomeric analog of copper, zinc superoxide dismutase

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12 December 2020

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

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12 December 2020

The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status

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12 December 2020

Equilibrium thermodynamic analysis of amyotrophic lateral sclerosis-associated mutant apo Cu,Zn superoxide dismutases

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12 December 2020

Mapping the folding free energy surface for metal-free human Cu,Zn superoxide dismutase

1 reference

12 December 2020

10.1016/J.JMB.2010.02.034

Identifiers

DOI

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4 August 2017

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4 August 2017

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