The ketolides: a critical review (Q34767447)

4 August 2017

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title

The ketolides: a critical review (English)

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4 August 2017

8

Stephen Douthwaite

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4 August 2017

1

George G Zhanel

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4 August 2017

Michael Walters

2

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4 August 2017

Ayman Noreddin

3

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4 August 2017

Lavern M Vercaigne

4

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4 August 2017

Aleksandra Wierzbowski

5

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4 August 2017

John M Embil

6

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4 August 2017

Alfred S Gin

7

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4 August 2017

Daryl J Hoban

9

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4 August 2017

1 January 2002

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4 August 2017

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4 August 2017

62

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4 August 2017

1771-1804

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4 August 2017

12

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https://scigraph.springernature.com/pub.10.2165/00003495-200262120-00006

4 August 2017

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cites work

Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage

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12 December 2020

In-vitro activity of ketolides against mycoplasmas

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12 December 2020

In vitro activity of the novel ketolide HMR 3647 and comparative oral antibiotics against Canadian respiratory tract isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis

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12 December 2020

Ketolides lack inducibility properties of MLS(B) resistance phenotype

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12 December 2020

Macrolide-resistant Streptococcus pneumoniae in Canada during 1998-1999: prevalence of mef(A) and erm(B) and susceptibilities to ketolides

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12 December 2020

Lung concentrations of telithromycin after oral dosing

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12 December 2020

In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.

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12 December 2020

Comparative in-vitro activity of ketolide HMR 3647 and four macrolides against gram-positive cocci of known erythromycin susceptibility status

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12 December 2020

The bactericidal activities of HMR 3004, HMR 3647 and erythromycin against gram-positive bacilli and development of resistance.

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12 December 2020

Synthesis of 2-fluoro-6-O-propargyl-11,12-carbamate ketolides. A novel class of antibiotics

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12 December 2020

Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides

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12 December 2020

In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae

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12 December 2020

In vitro pharmacodynamics of the new ketolides HMR 3004 and HMR 3647 (Telithromycin) against Chlamydia pneumoniae

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12 December 2020

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

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12 December 2020

In vitro activities of the ketolide HMR 3647 against recent gram-positive clinical isolates and Haemophilus influenzae

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12 December 2020

Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surve

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12 December 2020

Antibacterial activity of RU 64004 (HMR 3004), a novel ketolide derivative active against respiratory pathogens

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12 December 2020

Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America

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12 December 2020

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

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12 December 2020

In vitro pharmacodynamic studies of activities of ketolides HMR 3647 (Telithromycin) and HMR 3004 against extracellular or intracellular Helicobacter pylori

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12 December 2020

Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004)

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12 December 2020

In vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae.

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12 December 2020

In vitro activity of the new ketolide telithromycin compared with those of macrolides against Streptococcus pyogenes: influences of resistance mechanisms and methodological factors

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12 December 2020

In vitro activity of ketolides HMR 3004 and HMR 3647 and seven other antimicrobial agents against Corynebacterium diphtheriae

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12 December 2020

Influence of Pharmacokinetic and Pharmacodynamic Principles on Antibiotic Selection

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12 December 2020

Interactions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils.

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12 December 2020

Comparative in vitro activity of ABT-773, a novel antibacterial ketolide

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12 December 2020

Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils

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12 December 2020

In vitro activity of ABT-773 against Legionella pneumophila, its pharmacokinetics in guinea pigs, and its use to treat guinea pigs with L. pneumophila pneumonia

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12 December 2020

Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect

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12 December 2020

Activities of antimicrobial agents against intracellular pneumococci

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12 December 2020

The in-vitro activity of HMR 3647, a new ketolide antimicrobial agent.

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12 December 2020

Activities of HMR 3004 (RU 64004) and HMR 3647 (RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and eight other antimicrobial agents against unusual aerobic and anaerobic human and animal bite pathogens isol

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12 December 2020

Antipneumococcal activity of telithromycin by agar dilution, microdilution, E test, and disk diffusion methodologies

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12 December 2020

Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides.

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12 December 2020

In vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus species

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12 December 2020

Ketolide ABT-773 is active against Toxoplasma gondii

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12 December 2020

New research in macrolides and ketolides since 1997.

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12 December 2020

In vivo efficacy of the new ketolide telithromycin (HMR 3647) in murine infection models

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12 December 2020

The in vitro activity of ABT773, a new ketolide antimicrobial agent

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12 December 2020

In vitro activity of telithromycin (HMR3647), a new ketolide, against clinical isolates of Mycoplasma pneumoniae in Japan

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12 December 2020

Antianaerobic activity of the ketolide RU 64004 compared to activities of four macrolides, five beta-lactams, clindamycin, and metronidazole

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12 December 2020

Comparative antimicrobial activity and kill-curve investigations of novel ketolide antimicrobial agents (HMR 3004 and HMR 3647) tested against Haemophilus influenzae and Moraxella catarrhalis strains

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12 December 2020

Activity of telithromycin (HMR 3647) against anaerobic bacteria compared to those of eight other agents by time-kill methodology

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12 December 2020

Pharmacokinetics and comparative effects of telithromycin (HMR 3647) and clarithromycin on the oropharyngeal and intestinal microflora

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12 December 2020

Efficacy of telithromycin (HMR 3647) against enterococci in a mouse peritonitis model

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12 December 2020

Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by 11 different ketolide antibiotics.

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12 December 2020

Macrolide resistance conferred by base substitutions in 23S rRNA.

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12 December 2020

Patterns of phenotypic resistance to the macrolide-lincosamide-ketolide-streptogramin group of antibiotics in staphylococci.

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12 December 2020

Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents

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12 December 2020

In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to two ketolides (HMR 3004 and HMR 3647), four macrolides (azithromycin, clarithromycin, erythromycin A, and roxithromycin), and two ansamycins (rifampin and rifapentine)

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12 December 2020

Effects of macrolide antibiotics on CYP3A expression in human and rat hepatocytes: interspecies differences in response to troleandomycin.

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12 December 2020

The ketolide antibiotics HMR 3647 and HMR 3004 are active against Toxoplasma gondii in vitro and in murine models of infection

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12 December 2020

The effects of ketolides on bioactive phospholipid-induced injury to human respiratory epithelium in vitro.

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12 December 2020

Postantibiotic effects of ABT-773 and amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae

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12 December 2020

In vitro activities of ketolides HMR 3647 [correction of HRM 3647] and HMR 3004 [correction of HRM 3004], levofloxacin, and other quinolones and macrolides against Neisseria spp. and Moraxella catarrhalis

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12 December 2020

In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004

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12 December 2020

In vitro activity of ABT-773 versus macrolides and quinolones against resistant respiratory tract pathogens

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12 December 2020

Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

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12 December 2020

In vitro activity of a novel ketolide ABT-773 against invasive strains of Streptococcus pneumoniae

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12 December 2020

In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci

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12 December 2020

Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens

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12 December 2020

Superiority of 11,12 carbonate macrolide antibiotics as inhibitors of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells

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12 December 2020

Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.

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12 December 2020

Immunomodulating effects of HMR 3004 on pulmonary inflammation caused by heat-killed Streptococcus pneumoniae in mice.

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12 December 2020

A new ketolide, HMR 3004, active against streptococci inducibly resistant to erythromycin

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12 December 2020

In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis

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12 December 2020

Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

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12 December 2020

In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against Coryneform bacteria

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12 December 2020

Antibacterial effect of telithromycin (HMR 3647) and comparative antibiotics against intracellular Legionella pneumophila

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12 December 2020

Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae

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12 December 2020

In-vitro activities of 11 antibiotics against 75 strains of Streptococcus pneumoniae with reduced susceptibilities to penicillin isolated from patients in Washington State

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12 December 2020

Structure-activity relationships for six ketolide antibiotics

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12 December 2020

In vitro development of resistance to telithromycin (HMR 3647), four macrolides, clindamycin, and pristinamycin in Streptococcus pneumoniae

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12 December 2020

Pharmacodynamic properties of HMR 3004, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time kill kinetics and postantibiotic effect.

1 reference

12 December 2020

1 reference

12 December 2020

In vitro activity of telithromycin (HMR 3647) and seven other antimicrobial agents against anaerobic bacteria

1 reference

12 December 2020

Activities of telithromycin (HMR 3647, RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and other antimicrobial agents against unusual anaerobes

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12 December 2020

Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the SENTRY Antimicrobial Surveillance Program, 1997-1999.

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12 December 2020

Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin.

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12 December 2020

In-vitro antimicrobial activity of HMR 3004 (RU 64004) against erythromycin A-sensitive and -resistant Corynebacterium spp. isolated from clinical specimens

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12 December 2020

In vitro activities of ABT-773, a new ketolide, against aerobic and anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis

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12 December 2020

Activity of HMR 3647 compared to those of six compounds against 235 strains of Enterococcus faecalis.

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12 December 2020

In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria

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12 December 2020

Comparative in vitro activities of ABT-773 against 362 clinical isolates of anaerobic bacteria

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12 December 2020

In vitro activity of ABT-773 against anaerobic bacteria

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12 December 2020

Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model

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12 December 2020

Effect of proinflammatory cytokines on the interplay between roxithromycin, HMR 3647, or HMR 3004 and human polymorphonuclear neutrophils

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12 December 2020

Efficacies of ABT-773, a new ketolide, against experimental bacterial infections

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12 December 2020

Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains in Italy and heterogeneity of inducibly resistant strains

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12 December 2020

Review of macrolides and ketolides: focus on respiratory tract infections

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12 December 2020

In vitro activities of the new ketolide antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany.

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12 December 2020

Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens

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12 December 2020

Crystal structure of the ribosome at 5.5 A resolution

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12 December 2020

Conformational analysis of ketolide, conformations of RU 004 in solution and bound to bacterial ribosomes

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12 December 2020

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12 December 2020

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

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12 December 2020

Ketolides-telithromycin, an example of a new class of antibacterial agents

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12 December 2020

Need for annual surveillance of antimicrobial resistance in Streptococcus pneumoniae in the United States: 2-year longitudinal analysis

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12 December 2020

Macrolide resistance and erythromycin resistance determinants among Belgian Streptococcus pyogenes and Streptococcus pneumoniae isolates.

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12 December 2020

Susceptibilities of penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, compared with susceptibilities to 17 other agents

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12 December 2020

In vitro and in vivo efficacy of a novel fluoro-ketolide HMR 3562 against enterococci

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12 December 2020

Comparative in vitro activities of ABT-773 against aerobic and anaerobic pathogens isolated from skin and soft-tissue animal and human bite wound infections

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12 December 2020

Antimicrobial activity of RU-66647, a new ketolide

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12 December 2020

HMR 3647 human-like treatment of experimental pneumonia due to penicillin-resistant and erythromycin-resistant Streptococcus pneumoniae

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12 December 2020

In-vitro activity of the new ketolide antibiotic HMR 3647 against gram-positive bacteria.

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12 December 2020

Activity of HMR 3647 compared to those of five agents against Haemophilus influenzae and moraxella catarrhalis by MIC determination and time-kill assay

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12 December 2020

Antipneumococcal activities of a ketolide (HMR 3647), a streptogramin (quinupristin-dalfopristin), a macrolide (erythromycin), and a lincosamide (clindamycin).

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12 December 2020

Novelties in the field of anti-infective compounds in 1999.

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12 December 2020

In-vitro activity of HMR 3647 against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and beta-haemolytic streptococci

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12 December 2020

Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants

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12 December 2020

In vitro activities of the new ketolide HMR 3647 (telithromycin) in comparison with those of eight other antibiotics against viridans group Streptococci isolated from blood of neutropenic patients with cancer

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12 December 2020

Comparative activities of telithromycin (HMR 3647), levofloxacin, and other antimicrobial agents against human mycoplasmas

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12 December 2020

In vitro activity of ketolides telithromycin and HMR 3004 against italian isolates of Streptococcus pyogenes and Streptococcus pneumoniae with different erythromycin susceptibility.

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12 December 2020

The new ketolide HMR3647 accumulates in the azurophil granules of human polymorphonuclear cells

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12 December 2020

Antipneumococcal activity of ABT-773 compared to those of 10 other agents

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12 December 2020

Antibacterial activity of telithromycin (HMR 3647) in relation to in vitro simulated human plasma kinetics

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12 December 2020

Susceptibilities of 228 penicillin- and erythromycin-susceptible and -resistant pneumococci to RU 64004, a new ketolide, compared with susceptibilities to 16 other agents

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12 December 2020

In vitro activity of the ketolide HMR 3647 (RU 6647) for Legionella spp., its pharmacokinetics in guinea pigs, and use of the drug to treat guinea pigs with Legionella pneumophila pneumonia.

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12 December 2020

Ketolide treatment of Haemophilus influenzae experimental pneumonia

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12 December 2020

In vitro activities of a new ketolide, ABT-773, alone and in combination with amoxicillin, metronidazole, or tetracycline against Helicobacter pylori

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12 December 2020

The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA.

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12 December 2020

Uptake and intracellular activity of ketolide HMR 3647 in human phagocytic and non-phagocytic cells.

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12 December 2020

Kinetic study of the inflammatory response in Streptococcus pneumoniae experimental pneumonia treated with the ketolide HMR 3004.

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12 December 2020

In vitro susceptibilities of aerobic and facultative non-spore-forming gram-positive bacilli to HMR 3647 (RU 66647) and 14 other antimicrobials.

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12 December 2020

In vitro activities of two ketolides, HMR 3647 and HMR 3004, against gram-positive bacteria

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12 December 2020

Postantibiotic suppression of growth of erythromycin A-susceptible and -resistant gram-positive bacteria by the ketolides telithromycin (HMR 3647) and HMR 3004

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12 December 2020

Pharmacokinetics of the new ketolide telithromycin (HMR 3647) administered in ascending single and multiple doses

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12 December 2020

Comparative in vitro activity of telithromycin (HMR 3647), three macrolides, amoxycillin, cefdinir and levofloxacin against gram-positive clinical isolates in Japan.

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12 December 2020

Use of ketolides in combination with other drugs to treat experimental toxoplasmosis

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12 December 2020

Pharmacodynamics of telithromycin In vitro against respiratory tract pathogens

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12 December 2020

In vitro activity of telithromycin (HMR 3647) against 502 strains of anaerobic bacteria

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12 December 2020

In vitro activity of ABT-773, telithromycin and eight other antimicrobials against erythromycin-resistant Streptococcus pneumoniae respiratory isolates of children

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12 December 2020

In vitro antibacterial activities of telithromycin, a new ketolide, against bacteria causing infections in obstetric and gynaecological patients

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12 December 2020

10.2165/00003495-200262120-00006

Identifiers

DOI

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Dimensions Publication ID

4 August 2017

1033713564

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release_2bnjrgneave2fd2hu2st6ynrmi

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Fatcat

https://api.fatcat.wiki/v0/release/2bnjrgneave2fd2hu2st6ynrmi

24 November 2022

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