shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development (Q34764944)

https://doi.org/10.1016/j.stem.2023.05.009

4 August 2017

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29 December 2023

title

shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development (English)

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4 August 2017

6

Sally Temple

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4 August 2017

Christopher A Fasano

1

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4 August 2017

John T Dimos

2

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4 August 2017

Natalia B Ivanova

3

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4 August 2017

Natalia Lowry

4

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4 August 2017

Ihor R Lemischka

5

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4 August 2017

language of work or name

English

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publication date

1 June 2007

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4 August 2017

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4 August 2017

1

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4 August 2017

1

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4 August 2017

87-99

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Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death

4 August 2017

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Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon.

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Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

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pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F

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Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

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Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

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Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells

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The role of transforming growth factor beta in glioma progression

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Cancerous stem cells can arise from pediatric brain tumors

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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The retinoblastoma protein pathway and the restriction point

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

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Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.

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Polycomb complexes and silencing mechanisms.

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p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

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The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells.

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E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells

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The regulation of E2F by pRB-family proteins

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells

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Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

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Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.

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Microarray data normalization and transformation

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Do cells need CDK2 and ... Bcr-Abl?

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Polycomb silencers control cell fate, development and cancer

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Regenerative response in ischemic brain restricted by p21cip1/waf1

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Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma

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Searching chromatin for stem cell identity

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RNAi reveals doublecortin is required for radial migration in rat neocortex

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Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex

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Regulation of cerebral cortical size by control of cell cycle exit in neural precursors

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beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

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Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells.

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The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells

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p21 is a universal inhibitor of cyclin kinases

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

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Dissecting self-renewal in stem cells with RNA interference

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9 February 2024

https://opencitations.net/index/api/v1/references/10.1016/J.STEM.2007.04.001

Identifiers

DOI

10.1016/J.STEM.2007.04.001

1 reference

4 August 2017

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