Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo (Q34749403)

4 August 2017

Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo (English)

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4 August 2017

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5

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4 August 2017

E G Brain

1

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4 August 2017

L J Yu

series ordinal

2

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4 August 2017

K Gustafsson

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3

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4 August 2017

P Drewes

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4

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4 August 2017

language of work or name

English

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publication date

1 June 1998

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British Journal of Cancer

4 August 2017

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4 August 2017

77

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4 August 2017

11

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4 August 2017

1768-1776

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https://scigraph.springernature.com/pub.10.1038/bjc.1998.295

4 August 2017

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7 July 2018

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P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

7 July 2018

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Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

7 July 2018

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2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity

7 July 2018

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Pharmacokinetics and molecular detoxication

7 July 2018

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The history of the oxazaphosphorine cytostatics

7 July 2018

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7 July 2018

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Ifosfamide, mesna, and nephrotoxicity in children

7 July 2018

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Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

7 July 2018

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Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

7 July 2018

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

7 July 2018

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Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy

7 July 2018

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Structural basis of selective cytochrome P450 inhibition

7 July 2018

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Toxicity of single- vs. fractionated-dose ifosfamide in non-small cell lung cancer: a multi-center study.

7 July 2018

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Effect of microsomal activation on interaction between isophosphamide and DNA.

7 July 2018

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Inhibition of oxidative drug metabolism by orphenadrine: in vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics

7 July 2018

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Characterization of human microsomal cytochrome P-450 enzymes

7 July 2018

1 reference

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Pharmacologically guided phase I clinical trials based upon preclinical drug development

7 July 2018

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Mechanisms of cyclophosphamide action on hepatic P-450 expression

7 July 2018

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DNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

7 July 2018

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44 P450-catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography

7 July 2018

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Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats

7 July 2018

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The human hepatic cytochromes P450 involved in drug metabolism

7 July 2018

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Phenobarbital induction of cytochrome P-450 gene expression

7 July 2018

1 reference

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Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

7 July 2018

1 reference

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Suppression of rat hepatic microsomal cytochromes P450 by cyclophosphamide is correlated with plasma thyroid hormone levels and displays differential strain sensitivity.

26 October 2018

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Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard.

26 October 2018

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Ondansetron compared with dexamethasone and metoclopramide as antiemetics in the chemotherapy of breast cancer with cyclophosphamide, methotrexate, and fluorouracil.

26 October 2018

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Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene

26 October 2018

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Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450

26 October 2018

1 reference

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Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

9 December 2018

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Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver

9 December 2018

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Hypoactivity of cytochrome P-450 after triacetyloleandomycin administration

9 December 2018

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12 December 2020

IMVP-16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy

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12 December 2020

Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5

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12 December 2020

Dechloroethylation of ifosfamide and neurotoxicity

1 reference

12 December 2020

Digitoxin metabolism by liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase and its role in the protection of rats from digitoxin toxicity by pregnenolone-16 alpha-carbonitrile

1 reference

12 December 2020

Fluorometric determination of acrolein and related compounds with m-aminophenol

1 reference

12 December 2020

Ifosfamide: should the honeymoon be over?

1 reference

12 December 2020

Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients

1 reference

12 December 2020

Metabolism of docetaxel by human cytochromes P450: interactions with paclitaxel and other antineoplastic drugs

1 reference

12 December 2020

Intrasubject variation in children of ifosfamide pharmacokinetics and metabolism during repeated administration

1 reference

12 December 2020

Metabolite complex formation of orphenadrine with cytochrome P450. Involvement of CYP2C11 and CYP3A isozymes

1 reference

12 December 2020

Interferon gamma down-regulates cytochrome P450 3A genes in primary cultures of well-differentiated rat hepatocytes

1 reference

12 December 2020

Cyclophosphamide versus ifosfamide: final report of a randomized phase II trial in adult soft tissue sarcomas

1 reference

12 December 2020

Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase

1 reference

12 December 2020

Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes

1 reference

12 December 2020

Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy

1 reference

12 December 2020

Influence of phenobarbital induction on the enantioselective N-dechloroethylation of ifosfamide enantiomers in the rat

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1998.295

1 reference

Dimensions Publication ID

4 August 2017

0 references

1 reference

4 August 2017

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