Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects. (Q34725259)

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English	Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects.	scientific article

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29 December 2019

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Europe PubMed Central

Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects (English)

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29 December 2019

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neurophysiology

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author name string

Andrew K Evans

1

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29 December 2019

Christopher A Lowry

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29 December 2019

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1 January 2007

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29 December 2019

CNS Neuroscience & Therapeutics

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29 December 2019

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29 December 2019

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29 December 2019

475-501

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Europe PubMed Central

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29 December 2019

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00025.X

21 January 2018

The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00025.X

21 January 2018

Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2007.00025.X

21 January 2018

Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

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inferred from PubMed ID database lookup

Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of accumbens and cortical dopamine receptors in the regulation of cortical acetylcholine release.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Median raphe serotonergic innervation of medial septum/diagonal band of broca (MSDB) parvalbumin-containing neurons: possible involvement of the MSDB in the desynchronization of the hippocampal EEG.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic inputs to the rat medial prefrontal cortex mediate potentiation of the cardiovascular defensive response by the anxiogenic benzodiazephine receptor partial inverse agonist FG 7142.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increases in cortical acetylcholine release during sustained attention performance in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and neuronal substrate for the selective attenuation of anxiety.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of the hypnotic zolpidem in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of stress- or anxiogenic-drug-induced increases in dopamine release in the rat prefrontal cortex by long-term treatment with antidepressant drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that long-lasting potentiation of amygdala efferents in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of GABA tone in initiation of brain and behavioural changes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABA(A) receptor subtypes: dissecting their pharmacological functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cognitive neuroscience of sustained attention: where top-down meets bottom-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychotogenic properties of benzodiazepine receptor inverse agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

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Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theta oscillations in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by venlafaxine of the increase in norepinephrine output in rat prefrontal cortex elicited by acute stress or by the anxiogenic drug FG 7142.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions at GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subunit composition, distribution and function of GABA(A) receptor subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in accumbal dopaminergic transmission correlates with response cost not reward of hypothalamic stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Novel, Selective GABAAα5 Receptor Inverse Agonist Which Enhances Cognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A PET study following treatment with a pharmacological stressor, FG7142, in conscious rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurobiology and control of anxious states

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain differences in sensitivity to the hypothermic effects of benzodiazepine receptor ligands in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of Medial Prefrontal Cortex Decreases the Responsiveness of Central Amygdala Output Neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Methyl-beta-carboline-3-carboxamide (FG 7142), an anxiogenic agent in airborne particles and cigarette smoke-polluted indoor air

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of exposure level of N-methyl-beta-carboline-3-carboxamide (FG 7142), an anxiogenic agent in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of septo-hippocampal Theta activity by GABAA receptors: an experimental and computational approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiogenic treatments do not increase fear-potentiated startle in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Panicolytic-like effect induced by the stimulation of GABAA and GABAB receptors in the dorsal periaqueductal grey of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early life experience alters behavior during social defeat: focus on serotonergic systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of lactate metabolism in the basolateral amygdala by physical and psychological stress: role of benzodiazepine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Test-specific effects of FG-7142 on isolation-induced aggression in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of environmental and pharmacological stressors on c-fos and corticotropin-releasing factor mRNA in rat brain: Relationship to the reinstatement of alcohol seeking

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABA-based therapeutic approaches: GABAA receptor subtype functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence supporting a role for corticotropin-releasing factor type 2 (CRF2) receptors in the regulation of subpopulations of serotonergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recovery of fear memories in rats: role of gamma-amino butyric acid (GABA) in infantile amnesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced attention and increased impulsivity in mice lacking NPY Y2 receptors: relation to anxiolytic-like phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of 5-HT(1A) receptors in the modulation of stress-induced lactate metabolism in the medial prefrontal cortex and basolateral amygdala.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inverse agonist selective for alpha5 subunit-containing GABAA receptors improves encoding and recall but not consolidation in the Morris water maze.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety signal withdrawal: a behavioural paradigm sensitive to both "anxiolytic" and "anxiogenic" drugs under identical experimental conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro microdialysis: a novel technique for stimulated neurotransmitter release measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiety, respiration, and cerebral blood flow: implications for functional brain imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A developmental dissociation of context and GABA effects on extinguished fear in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effects of benzodiazepine and β-carboline inverse agonists on body temperature in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do adenosinergic substrates mediate methylxanthine effects upon reinforcement thresholds for electrical brain stimulation in the rat?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiogenic beta-carboline FG 7142 selectively increases dopamine release in rat prefrontal cortex as measured by microdialysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stressor-like effects of FG-7142 on medial prefrontal cortex self-stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of midazolam, DMCM and lindane on potentiated startle in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiogenic beta-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in GABAergic transmission induced by stress, anxiogenic and anxiolytic beta-carbolines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of anxiety by beta-carbolines and other benzodiazepine receptor ligands: relationship of pharmacological to biochemical measures of efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional changes in the consumption of food produced by beta-carbolines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional effects of chronic treatment with agonists and inverse agonists at the benzodiazepine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain differences in response to a benzodiazepine receptor inverse agonist (FG 7142) in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-carbolines can enhance or antagonize the effects of punishment in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of adenosine in the central actions of the benzodiazepines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic benzodiazepine treatment increases the effects of the inverse agonist FG7142.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), an inverse agonist at benzodiazepine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine receptor ligands and the consumption of a highly palatable diet in non-deprived male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An anxiogenic benzodiazepine receptor ligand induces learned helplessness.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Carboline FG 7142-reduced aggression in male rats: reversed by the benzodiazepine receptor antagonist, Ro15-1788.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of chronic treatment with benzodiazepine receptor ligands on cortical adrenoceptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic treatment with lorazepam and FG 7142 may change the effects of benzodiazepine receptor agonists, antagonists and inverse agonists by different mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single dose of FG 7142 causes long-term increases in mouse cortical β-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of the immune response by benzodiazepine receptor inverse agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of an anxiogenic benzodiazepine receptor ligand on motor activity and dopamine release in nucleus accumbens and striatum in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of nucleus accumbens amphetamine on lateral hypothalamic brain stimulation reward.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of beta-carbolines in animal models of anxiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FG 7142 and its anxiety-inducing effects in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-Carbolines with agonistic and inverse agonistic properties at benzodiazepine receptors of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of ?-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepine receptor-mediated experimental "anxiety" in primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Carbolines enhance shock-induced suppression of drinking in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic and antagonistic effects of beta-carboline FG 7142 on behavioral and EEG actions of benzodiazepines and pentobarbital in cats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiogenic action of FG 7142 in the social interaction test is reversed by chlordiazepoxide and Ro 15-1788 but not by CGS 8216.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Carboline-induced anxiety states.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of the beta-carboline FG 7142, on intracranial self-stimulation in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142 in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stressor controllability, social interaction, and benzodiazepine systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethopharmacological analysis of the effects of putative 'anxiogenic' agents in the mouse elevated plus-maze.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Which GABAA-receptor subtypes really occur in the brain?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and pharmacology of human GABAA receptors containing gamma 3 subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of social dominance on self-stimulation behavior in male golden hamsters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of FG 7142-induced increased dopamine utilization by the glycine/NMDA receptor antagonist (+)-HA 966

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposed regulation by dorsal raphe nucleus 5-HT pathways of two types of fear in the elevated T-maze.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A central cholinergic link in the cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine and spatial working memory in rats and monkeys: pharmacological reversal of stress-induced impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brainstem-diencephalo-septohippocampal systems controlling the theta rhythm of the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepines, anxiety and immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiovascular and somatic startle and defense: concordant and discordant actions of benzodiazepine receptor agonists and inverse agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiogenic agents, yohimbine and FG 7142, disrupt the noradrenergic response to novelty.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiety and cardiovascular reactivity: the basal forebrain cholinergic link.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that GABA transmission mediates context-specific extinction of learned fear.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18078430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1527-3458.2007.00025.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18078430%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18078430%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18078430%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

ResearchGate publication ID

0 references

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